ALAS1 and WIPF1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid)

		ALAS1	WIPF1
Description		5'-aminolevulinate synthase 1	WAS/WASL interacting protein family member 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Matrix Cytosol	Ruffle Cytosol Actin Filament Actin Cytoskeleton Cytoplasmic Vesicle
	Molecular Function	5-aminolevulinate Synthase Activity Protein Binding Pyridoxal Phosphate Binding Identical Protein Binding	Actin Binding Protein Binding Profilin Binding SH3 Domain Binding
	Biological Process	Protoporphyrinogen IX Biosynthetic Process Heme Biosynthetic Process Hemoglobin Biosynthetic Process Erythrocyte Development	Actin Polymerization Or Depolymerization Actin Filament-based Movement Protein-containing Complex Assembly
Pathways		Heme biosynthesis PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis	Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs CDC42 GTPase cycle RAC1 GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs		Pyridoxal phosphate Pyridoxal phosphate Glycine
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972) Parkinson's disease ( 28892059) Schizophrenia ( 23974872)	Atrial fibrillation ( 30061737 29892015) Mean platelet volume ( 32888494) Platelet distribution width ( 32888494) Pulse pressure ( 27841878) Resting heart rate ( 27798624) Systolic blood pressure ( 27841878) Urate levels (BMI interaction) ( 25811787)
Interacting Genes		55 interacting genes: BCL7A C2orf42 C8orf33 CAP2 CCHCR1 CDC73 CDK5 CDKN1A CERK COBL DUSP19 EP400 FBXL8 FXR1 GNL3L GRXCR1 HSBP1L1 JRK KIF9 KLHL35 LONRF1 LRRC45 MTFR2 MTSS2 NUDT3 OXTR PIBF1 PIK3CB PLAU POLDIP2 PPL RAP1B RNF168 RTL8B SH2D4A SNRPB2 SNX20 STAMBP SUMO2 TCEA2 TEKT4 TK1 TMSB10 TMSB4X TMSB4XP1 TMSB4XP2 TMSB4XP6 TTC23 USP20 UTP14C WIPF1 ZFYVE26 ZMAT1 ZNF175 ZNF564	27 interacting genes: ABI2 ACTC1 ACTG1 ALAS1 APBB1 CACNG2 CDC42 CRKL CTTN FASTK GRB2 HCK HLCS HOMER3 ITSN2 NCK1 NCK2 PRKCQ PRPF40A RER1 SEC24C SH3RF1 WAS WASL WBP4 WWP2 ZAP70
Entrez ID		211	7456
HPRD ID		00505	03835
Ensembl ID		ENSG00000023330	ENSG00000115935
Uniprot IDs		B4DVA0 P13196 Q5JAM2	A0A140VJZ9 O43516 Q2YDC4
PDB IDs			2A41
Enriched GO Terms of Interacting Partners?
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