AKT2 and PDPK1

Number of citations of the paper that reports this interaction (PubMedID 9374542)
93

Data Source:
HPRD (in vitro, in vivo)

		AKT2	PDPK1
Description		AKT serine/threonine kinase 2	3-phosphoinositide dependent protein kinase 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Early Endosome Cytosol Plasma Membrane Cell Cortex Ruffle Membrane Protein-containing Complex Intracellular Membrane-bounded Organelle	Nucleus Cytoplasm Cytosol Plasma Membrane Focal Adhesion Postsynaptic Density Membrane Cytoplasmic Vesicle Cell Projection Perikaryon
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Metal Ion Binding Protein Serine Kinase Activity	Protein Serine/threonine Kinase Activity 3-phosphoinositide-dependent Protein Kinase Activity Insulin Receptor Binding Protein Binding ATP Binding Phospholipase Activator Activity Protein Kinase Binding Phospholipase Binding Protein Serine Kinase Activity
	Biological Process	Positive Regulation Of Protein Phosphorylation Glycogen Biosynthetic Process Glucose Metabolic Process Regulation Of Translation Cellular Protein Modification Process Signal Transduction Positive Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Carbohydrate Transport Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Positive Regulation Of Glucose Metabolic Process Positive Regulation Of Mitochondrial Membrane Potential Peptidyl-serine Phosphorylation Regulation Of Cell Migration Positive Regulation Of Cell Migration Positive Regulation Of Vesicle Fusion Positive Regulation Of Fatty Acid Beta-oxidation Peripheral Nervous System Myelin Maintenance Cellular Response To Insulin Stimulus Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Fat Cell Differentiation Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Glucose Import Regulation Of Cell Cycle Mammary Gland Epithelial Cell Differentiation Intracellular Protein Transmembrane Transport Cellular Response To High Light Intensity Protein Localization To Plasma Membrane Positive Regulation Of Protein Targeting To Membrane Activation Of GTPase Activity Retinal Rod Cell Apoptotic Process Positive Regulation Of Cell Motility	Type B Pancreatic Cell Development Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Hyperosmotic Response Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Phospholipase Activity Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Cell Migration Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Calcium-mediated Signaling Actin Cytoskeleton Organization Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Activation Of Protein Kinase B Activity Cellular Response To Insulin Stimulus Negative Regulation Of Toll-like Receptor Signaling Pathway Intracellular Signal Transduction Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Mast Cell Degranulation Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Angiogenesis Protein Autophosphorylation Focal Adhesion Assembly Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cellular Response To Epidermal Growth Factor Stimulus Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Sprouting Angiogenesis Positive Regulation Of Vascular Endothelial Cell Proliferation Cellular Response To Brain-derived Neurotrophic Factor Stimulus Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways		Activation of BAD and translocation to mitochondria PIP3 activates AKT signaling PIP3 activates AKT signaling Downregulation of ERBB2:ERBB3 signaling Translocation of SLC2A4 (GLUT4) to the plasma membrane Activation of AKT2 PDE3B signalling Inhibition of TSC complex formation by PKB AKT phosphorylates targets in the cytosol AKT phosphorylates targets in the cytosol AKT phosphorylates targets in the nucleus Negative regulation of the PI3K/AKT network AKT-mediated inactivation of FOXO1A Deactivation of the beta-catenin transactivating complex CD28 dependent PI3K/Akt signaling CTLA4 inhibitory signaling G beta:gamma signalling through PI3Kgamma VEGFR2 mediated vascular permeability TP53 Regulates Metabolic Genes Constitutive Signaling by AKT1 E17K in Cancer Regulation of TP53 Degradation Regulation of TP53 Activity through Acetylation Regulation of TP53 Activity through Association with Co-factors Cyclin E associated events during G1/S transition Cyclin A:Cdk2-associated events at S phase entry RAB GEFs exchange GTP for GDP on RABs RUNX2 regulates genes involved in cell migration Regulation of PTEN stability and activity FLT3 Signaling Regulation of localization of FOXO transcription factors Estrogen-dependent nuclear events downstream of ESR-membrane signaling	GPVI-mediated activation cascade GPVI-mediated activation cascade PIP3 activates AKT signaling Activation of AKT2 Downstream TCR signaling Role of LAT2/NTAL/LAB on calcium mobilization FCERI mediated NF-kB activation Integrin signaling CD28 dependent PI3K/Akt signaling G beta:gamma signalling through PI3Kgamma RSK activation VEGFR2 mediated vascular permeability VEGFR2 mediated cell proliferation CLEC7A (Dectin-1) signaling RHO GTPases activate PKNs Constitutive Signaling by AKT1 E17K in Cancer Regulation of TP53 Degradation Estrogen-stimulated signaling through PRKCZ Estrogen-stimulated signaling through PRKCZ
Drugs		N-[(1S)-2-amino-1-phenylethyl]-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)thiophene-2-carboxamide 4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINE ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDE (2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE	Celecoxib Inositol 1,3,4,5-Tetrakisphosphate 7-Hydroxystaurosporine Bisindolylmaleimide VIII Staurosporine Bisindolylmaleimide I Dexfosfoserine 10,11-dimethoxy-4-methyldibenzo[c,f]-2,7-naphthyridine-3,6-diamine 5-HYDROXY-3-[(1R)-1-(1H-PYRROL-2-YL)ETHYL]-2H-INDOL-2-ONE 1-{2-OXO-3-[(1R)-1-(1H-PYRROL-2-YL)ETHYL]-2H-INDOL-5-YL}UREA 2-(1H-imidazol-1-yl)-9-methoxy-8-(2-methoxyethoxy)benzo[c][2,7]naphthyridin-4-amine 3-(1H-indol-3-yl)-4-(1-{2-[(2S)-1-methylpyrrolidinyl]ethyl}-1H-indol-3-yl)-1H-pyrrole-2,5-dione 3-[1-(3-AMINOPROPYL)-1H-INDOL-3-YL]-4-(1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE Fostamatinib
Diseases
GWAS		Birth weight ( 31043758) Cerebrospinal fluid t-tau:AB1-42 ratio ( 26252872) Cerebrospinal T-tau levels ( 26252872) Diastolic blood pressure ( 28739976) Lean body mass ( 28552196) Lymphocyte counts ( 32888494)	Hip circumference adjusted for BMI ( 34021172)
Interacting Genes		44 interacting genes: ABCG8 AKT1 AKT1S1 APOA1 APOB APP APPL1 BLVRA CCL14 CDKN1A CHUK CLIP3 ESR1 FOXO4 FSHR GSK3B H3C1 HSP90AA1 MEOX2 MTCP1 NAMPT PDPK1 PICK1 PIP5K1C PLEKHO1 PNPLA3 POFUT1 POLR1B PRKDC RAB3D REL SH3RF1 SLC2A4 SNX27 SORBS2 SORBS3 SPRR2A STEAP4 TCL1A TCL1B TMED2 TRIB3 TSC2 XIAP	63 interacting genes: AKT1 AKT2 AKT3 AKTIP APBB3 APP BLMH CARD11 CDAN1 CSK DDIT4 GIT1 HSP90AA1 ILK IRS1 ITGB3 KATNBL1 LUC7L2 MAPK8 MTOR PAK1 PEA15 PHAX PIK3C3 PKD1 PKN1 PKN2 PNO1 POLDIP2 PRKACA PRKCB PRKCD PRKCE PRKCI PRKCZ PRSS23 PRXL2B PTK2B PXN RALGDS RPS6KA1 RPS6KA3 RPS6KB1 RPS6KB2 SBF1 SGK1 SGK2 SGK3 SLC9A3R2 SMARCB1 SOCS3 SRC SRPK1 STRAP TCAP UBE2I WDCP XPO7 XRCC6 YWHAH YWHAQ ZC3HC1 ZNF133
Entrez ID		208	5170
HPRD ID		01262	05556
Ensembl ID		ENSG00000105221	ENSG00000140992
Uniprot IDs		B4DG79 P31751	O15530
PDB IDs		1GZK 1GZN 1GZO 1MRV 1MRY 1O6K 1O6L 1P6S 2JDO 2JDR 2UW9 2X39 2XH5 3D0E 3E87 3E88 3E8D	1H1W 1OKY 1OKZ 1UU3 1UU7 1UU8 1UU9 1UVR 1W1D 1W1G 1W1H 1Z5M 2BIY 2PE0 2PE1 2PE2 2R7B 2VKI 2XCH 2XCK 3H9O 3HRC 3HRF 3ION 3IOP 3NAX 3NAY 3NUN 3NUS 3NUU 3NUY 3ORX 3ORZ 3OTU 3PWY 3QC4 3QCQ 3QCS 3QCX 3QCY 3QD0 3QD3 3QD4 3RCJ 3RWP 3RWQ 3SC1 4A06 4A07 4AW0 4AW1 4CT1 4CT2 4RQK 4RQV 4RRV 4XX9 5ACK 5HKM 5HNG 5HO7 5HO8 5LVL 5LVM 5LVN 5LVO 5LVP 5MRD 6WJQ
Enriched GO Terms of Interacting Partners?
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