ERCC5 and GTF2H4

Number of citations of the paper that reports this interaction (PubMedID 16246722)
93

Data Source:
HPRD (in vivo)

		ERCC5	GTF2H4
Description		ERCC excision repair 5, endonuclease	general transcription factor IIH subunit 4
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GO Annotations	Cellular Component	Nucleotide-excision Repair Complex Nucleus Nucleoplasm Protein-containing Complex	Core TFIIH Complex Portion Of Holo TFIIH Complex Transcription Factor TFIIH Core Complex Nucleus Nucleoplasm Transcription Factor TFIID Complex Transcription Factor TFIIH Holo Complex Nuclear Speck
	Molecular Function	Bubble DNA Binding RNA Polymerase II Complex Binding Damaged DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Endonuclease Activity Endodeoxyribonuclease Activity Protein Binding Enzyme Activator Activity Protein Homodimerization Activity Protein-containing Complex Binding Metal Ion Binding Protein N-terminus Binding	ATPase Activator Activity Double-stranded DNA Binding Protein Binding RNA Polymerase II General Transcription Initiation Factor Activity
	Biological Process	Double-strand Break Repair Via Homologous Recombination Transcription-coupled Nucleotide-excision Repair Base-excision Repair, AP Site Formation Nucleotide-excision Repair Nucleotide-excision Repair, DNA Incision, 3'-to Lesion Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Response To UV UV Protection Response To UV-C Negative Regulation Of Apoptotic Process Regulation Of Catalytic Activity	DNA Repair Nucleotide-excision Repair Transcription By RNA Polymerase II Regulation Of Catalytic Activity Phosphorylation Of RNA Polymerase II C-terminal Domain
Pathways		Formation of Incision Complex in GG-NER Dual Incision in GG-NER Dual incision in TC-NER	Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Tat-mediated elongation of the HIV-1 transcript NoRC negatively regulates rRNA expression Formation of Incision Complex in GG-NER Dual Incision in GG-NER RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes mRNA Capping RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Transcription Termination RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Metabolite levels ( 23823483) Urinary calcium excretion ( 31993563)	Autism spectrum disorder or schizophrenia ( 28540026) Conotruncal heart defects (maternal effects) ( 28468790) Malaria ( 31844061) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848) Schizophrenia ( 28991256) Ulcerative colitis ( 20848476)
Interacting Genes		12 interacting genes: BRCA1 BRCA2 ERCC2 ERCC6 EWSR1 GTF2H1 GTF2H4 HSPB1 NTHL1 PCNA POLR2A RAD51	16 interacting genes: DAXX EAF1 EIF1AD ERCC3 ERCC5 GTF2B GTF2E1 GTF2F1 GTF2H2 GTF2H3 NEK1 POLR2A SREK1IP1 TBP TP53 XBP1P1
Entrez ID		2073	2968
HPRD ID		00595	03456
Ensembl ID		ENSG00000134899	ENSG00000213780
Uniprot IDs		P28715	A0A1U9X7S4 Q92759
PDB IDs		5EKF 5EKG 6TUR 6TUS 6TUW 6TUX 6VBH	5IVW 5IY6 5IY7 5IY8 5IY9 5OF4 6NMI 6O9L 6O9M 6RO4
Enriched GO Terms of Interacting Partners?
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