ERCC3 and CDK8

Number of citations of the paper that reports this interaction (PubMedID 10993082)
138

Data Source:
BioGRID (enzymatic study)

		ERCC3	CDK8
Description		ERCC excision repair 3, TFIIH core complex helicase subunit	cyclin dependent kinase 8
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GO Annotations	Cellular Component	Nucleotide-excision Repair Factor 3 Complex Transcription Factor TFIIH Core Complex Nucleus Nucleoplasm Transcription Factor TFIID Complex Transcription Factor TFIIH Holo Complex Transcription Preinitiation Complex	Nucleus Nucleoplasm Nucleolus Mediator Complex Protein-containing Complex
	Molecular Function	DNA Binding Damaged DNA Binding Protein Binding ATP Binding Protein C-terminus Binding ATP Hydrolysis Activity 3'-5' DNA Helicase Activity Protein N-terminus Binding Promoter-specific Chromatin Binding	Protein Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Protein Serine Kinase Activity
	Biological Process	Nucleotide-excision Repair, DNA Duplex Unwinding Response To Hypoxia DNA Topological Change DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Transcription Elongation From RNA Polymerase I Promoter Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter Apoptotic Process Response To Oxidative Stress Protein Localization Response To UV UV Protection Nucleotide-excision Repair, DNA Incision Hair Cell Differentiation Positive Regulation Of Apoptotic Process Embryonic Organ Development Regulation Of Mitotic Cell Cycle Phase Transition	Protein Phosphorylation Regulation Of Cell Cycle
Pathways		Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Tat-mediated elongation of the HIV-1 transcript NoRC negatively regulates rRNA expression Formation of Incision Complex in GG-NER Dual Incision in GG-NER RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes mRNA Capping RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Transcription Termination RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE	PPARA activates gene expression NOTCH1 Intracellular Domain Regulates Transcription Generic Transcription Pathway SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation
Drugs			Alvocidib
Diseases
GWAS			Immune response to measles-mumps-rubella vaccine ( 24811271) Sporadic pituitary adenoma ( 26029870)
Interacting Genes		37 interacting genes: ADAMTSL4 AR BCR BLZF1 CCNC CCNH CDC42 CDK7 CDK8 CEP70 CEP76 E2F1 ERCC2 GOLGA2 GTF2E1 GTF2E2 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 KPNA3 MAGED1 MCF2 MNAT1 MSANTD2 PSMC5 RAD52 ROPN1 SNW1 SRPK2 TP53 TRIM14 TRIM27 XIAP XPC ZSCAN1	40 interacting genes: AURKA BCL6 BMPR1A BUB1 CCNC CCND1 CCNH CDH1 CDKN2B CTDP1 ERBB2 ERCC3 ESR1 ESR2 FLT1 FLT3 H3C14 KRAS MAML1 MBP MCC MED12 MED21 MED25 MED26 MED8 MED9 MLH3 MYC NRIP1 POLR2A PRMT5 SMAD2 SMAD3 SMARCA4 SREBF1 SUZ12 TOP1 TP53 WDR77
Entrez ID		2071	1024
HPRD ID		00593	04422
Ensembl ID		ENSG00000163161	ENSG00000132964
Uniprot IDs		B3KRG2 B3KTH1 G3V1S1 P19447	P49336
PDB IDs		4ERN 5IVW 5IY6 5IY7 5IY8 5IY9 5OF4 6NMI 6O9L 6O9M 6RO4	3RGF 4CRL 4F6S 4F6U 4F6W 4F70 4F7J 4F7L 4F7N 4F7S 4G6L 5BNJ 5CEI 5FGK 5HBE 5HBH 5HBJ 5HNB 5HVY 5I5Z 5ICP 5IDN 5IDP 5XQX 5XS2 6QTG 6QTJ 6R3S 6T41 6TPA 6Y0A
Enriched GO Terms of Interacting Partners?
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