EIF4EBP1 and RORC

Number of citations of the paper that reports this interaction (PubMedID 10405182)
15

Data Source:
HPRD (in vitro)

		EIF4EBP1	RORC
Description		eukaryotic translation initiation factor 4E binding protein 1	RAR related orphan receptor C
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Protein-containing Complex Glutamatergic Synapse Postsynaptic Cytosol	Chromatin Nucleus Nucleoplasm Nuclear Body
	Molecular Function	Protein Binding Eukaryotic Initiation Factor 4E Binding Translation Repressor Activity Protein Phosphatase 2A Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Oxysterol Binding Zinc Ion Binding Ligand-activated Transcription Factor Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Response To Ischemia Lung Development Negative Regulation Of Protein-containing Complex Assembly TOR Signaling Response To Ethanol Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of Translational Initiation Cellular Response To Hypoxia Response To Amino Acid Starvation	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Xenobiotic Metabolic Process Regulation Of Glucose Metabolic Process Regulation Of Steroid Metabolic Process Intracellular Receptor Signaling Pathway Circadian Regulation Of Gene Expression Cellular Response To Sterol Positive Regulation Of Circadian Rhythm Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription, DNA-templated Adipose Tissue Development T-helper 17 Cell Differentiation
Pathways		mTORC1-mediated signalling Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	Nuclear Receptor transcription pathway Interleukin-4 and Interleukin-13 signaling
Drugs
Diseases
GWAS		Menopause (age at onset) ( 29773799)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 30929738 31619474) Asthma (childhood onset) ( 30929738) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Depressive symptoms (SSRI exposure interaction) ( 25649181) Inflammatory bowel disease ( 28067908 23128233) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Ulcerative colitis ( 28067908)
Interacting Genes		41 interacting genes: AKT1 ATM BUB1 CHTF8 CSNK2A1 CSNK2A2 DDIT4L EIF4E EIF4E1B EIF4E2 FGFR1 GSK3B IRAK4 LATS1 LMO2 LRRK2 MAPK1 MAPK14 MAPKAPK5 MEOX1 MLST8 MTOR MVD NRG1 PICK1 PLAT POU6F2 PPP2CA PRKCA PRKDC PTPA REL RHEBL1 RICTOR RORC RPS6KA5 RPS6KB1 RPTOR STK3 TCF4 ZNF655	24 interacting genes: ARNTL2 BHLHE41 CHD4 CIPC CLOCK CSNK1E DELEC1 EIF4EBP1 EVI2A FBXL15 NCOA6 NPAS2 NR1D2 PER2 PPP1CA PPP1CB PPP1CC PPP2CA PPP2R1A PPP2R1B PPP2R5D PPP2R5E PSMC5 RORB
Entrez ID		1978	6097
HPRD ID		03746	04250
Ensembl ID		ENSG00000187840	ENSG00000143365
Uniprot IDs		Q13541	F1D8P6 P51449 Q6I9R9
PDB IDs		1EJ4 1EJH 1WKW 2JGB 2JGC 2V8W 2V8X 2V8Y 3HXG 3HXI 3M93 3M94 3U7X 4UED 5BXV 5EKV 5NVN 5WBJ 6BCU 6BCX	3B0W 3KYT 3L0J 3L0L 4NB6 4NIE 4QM0 4S14 4WLB 4WPF 4WQP 4XT9 4YMQ 4YPQ 4ZJR 4ZJW 4ZOM 5APH 5APJ 5APK 5AYG 5C4O 5C4S 5C4T 5C4U 5EJV 5ETH 5G42 5G43 5G44 5G45 5G46 5IXK 5IZ0 5K38 5K3L 5K3M 5K3N 5K6E 5K74 5LWP 5M96 5NI5 5NI7 5NI8 5NIB 5NTI 5NTK 5NTN 5NTP 5NTQ 5NTW 5NU1 5UFO 5UFR 5UHI 5VB3 5VB5 5VB6 5VB7 5VQK 5VQL 5W4R 5W4V 5X8Q 5YP5 5YP6 5ZA1 6A22 6B30 6B31 6B33 6BN6 6BR2 6BR3 6CN5 6CN6 6CVH 6E3E 6E3G 6ESN 6FGQ 6FZU 6G05 6G07 6IVX 6J1L 6J3N 6LO9 6LOA 6LOB 6LOC 6NAD 6NWS 6NWT 6NWU 6O3Z 6O98 6P9F 6Q2W 6Q6M 6Q6O 6Q7A 6Q7H 6R7A 6R7J 6R7K 6SAL 6SLZ 6T4G 6T4I 6T4J 6T4K 6T4T 6T4U 6T4W 6T4X 6T4Y 6T50 6TLM 6TLQ 6TLT 6U25 6UCG 6VQF 6VSW 6W9H 6W9I 6XAE 6XFV 7JH2 7JTM 7JYM 7KQJ 7KXD 7KXE 7KXF
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?