EIF4E and CD83

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		EIF4E	CD83
Description		eukaryotic translation initiation factor 4E	CD83 molecule
Image
GO Annotations	Cellular Component	P-body Nucleus Cytoplasm Cytosol MRNA Cap Binding Complex Cytoplasmic Stress Granule Eukaryotic Translation Initiation Factor 4F Complex RISC Complex Chromatoid Body Cytoplasmic Ribonucleoprotein Granule Perinuclear Region Of Cytoplasm Extracellular Exosome Glutamatergic Synapse Postsynaptic Cytosol	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane
	Molecular Function	RNA Cap Binding RNA 7-methylguanosine Cap Binding RNA Binding Translation Initiation Factor Activity Protein Binding Enzyme Binding Eukaryotic Initiation Factor 4G Binding DNA-binding Transcription Factor Binding	Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Behavioral Fear Response Translational Initiation Regulation Of Translation Negative Regulation Of Autophagy Negative Regulation Of Translation Stem Cell Population Maintenance Lung Development Negative Regulation Of Neuron Differentiation Positive Regulation Of Mitotic Cell Cycle Cellular Response To Dexamethasone Stimulus Regulation Of Translation At Postsynapse, Modulating Synaptic Transmission	Defense Response Humoral Immune Response Signal Transduction Response To Organic Cyclic Compound Negative Regulation Of Interleukin-4 Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation
Pathways		ISG15 antiviral mechanism L13a-mediated translational silencing of Ceruloplasmin expression Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript mTORC1-mediated signalling Deadenylation of mRNA Translation initiation complex formation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs		7-methyl-GpppA 7-methyl-7,8-dihydroguanosine-5'-diphosphate 7-methyl-guanosine-5'-triphosphate LY2275796 S-[(1-Hydroxy-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl] methanesulfonothioate
Diseases
GWAS		Alcohol consumption (drinks per week) ( 30643258 30679032) Alcohol dependence ( 33290381) Daytime sleep phenotypes ( 27126917) HDL cholesterol levels ( 32203549) Mean arterial pressure x educational attainment (graduated college) interaction (2df) ( 32372009) Menopause (age at onset) ( 29773799) Pulse pressure ( 33230300) Sensation seeking ( 30718321)	Breast cancer and/or colorectal cancer ( 29698419) California verbal learning test score ( 31596458) Chronotype ( 30696823) Obesity-related traits ( 23251661) Response to tofacitinib treatment (herpes zoster) ( 33455090) Response to tofacitinib treatment (herpes zoster)(time to event) ( 33455090) Response to tofacitinib treatment in psoriasis (herpes zoster) ( 33455090) Response to tofacitinib treatment in psoriasis (herpes zoster)(time to event) ( 33455090) Rheumatoid arthritis ( 30423114 22446963 24390342)
Interacting Genes		27 interacting genes: APP BIRC2 BRWD1 CD83 EIF4B EIF4EBP1 EIF4EBP2 EIF4EBP3 EIF4ENIF1 EIF4G1 EIF4G2 EIF4G3 EMX2 GEMIN5 KANK2 MAPKAPK5 MKNK1 MKNK2 PML PRDM4 PRKCA PRKCB PRKCG PTEN TDO2 TRIM27 UBXN11	10 interacting genes: EIF4E FAM8A1 FATE1 GCM2 GMPR KIF13A NOL7 PAPSS2 SACS SPP1
Entrez ID		1977	9308
HPRD ID		00591	05170
Ensembl ID		ENSG00000151247	ENSG00000112149
Uniprot IDs		D6RBW1 P06730 Q32Q75 X5D7E3	A0A087WX61 Q01151
PDB IDs		1IPB 1IPC 1WKW 2GPQ 2V8W 2V8X 2V8Y 2W97 3AM7 3TF2 3U7X 4AZA 4BEA 4DT6 4DUM 4TPW 4TQB 4TQC 4UED 5EHC 5EI3 5EIR 5EKV 5GW6 5T46 5ZJY 5ZJZ 5ZK5 5ZK7 5ZK9 5ZML	5MIX 5MJ0 5MJ1 5MJ2
Enriched GO Terms of Interacting Partners?
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