HiPPIP
Home
About
SZ Genes
People
Help
Advanced Search
EGF and CPM
Number of citations of the paper that reports this interaction (PubMedID
7615511
)
14
Data Source:
HPRD
(in vivo)
EGF
CPM
Description
epidermal growth factor
carboxypeptidase M
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Lysosomal Membrane
Plasma Membrane
Integral Component Of Membrane
Clathrin-coated Endocytic Vesicle Membrane
Platelet Alpha Granule Lumen
Extracellular Exosome
Extracellular Region
Extracellular Space
Plasma Membrane
Cell Surface
Anchored Component Of Membrane
Extracellular Exosome
Molecular Function
Guanyl-nucleotide Exchange Factor Activity
Epidermal Growth Factor Receptor Binding
Calcium Ion Binding
Protein Binding
Growth Factor Activity
Transmembrane Receptor Protein Tyrosine Kinase Activator Activity
Carboxypeptidase Activity
Metallocarboxypeptidase Activity
Zinc Ion Binding
Biological Process
Angiogenesis
Positive Regulation Of Endothelial Cell Proliferation
Positive Regulation Of Receptor Internalization
Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity
Epidermal Growth Factor Receptor Signaling Pathway
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of Endothelial Cell Migration
Positive Regulation Of Gene Expression
Positive Regulation Of Peptidyl-threonine Phosphorylation
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Peptidyl-tyrosine Phosphorylation
Positive Regulation Of Cerebellar Granule Cell Precursor Proliferation
Positive Regulation Of Cell Migration
Epidermal Growth Factor Receptor Signaling Pathway Via MAPK Cascade
Positive Regulation Of Phosphorylation
Positive Regulation Of DNA Binding
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of MAPK Cascade
Positive Regulation Of DNA Replication
Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity
Positive Regulation Of Mitotic Nuclear Division
Positive Regulation Of Transcription, DNA-templated
Regulation Of Receptor Signaling Pathway Via JAK-STAT
Branching Morphogenesis Of An Epithelial Tube
Negative Regulation Of Secretion
Positive Regulation Of Protein Kinase B Signaling
Mammary Gland Alveolus Development
ERK1 And ERK2 Cascade
Positive Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Calcium Ion Import
Negative Regulation Of Cholesterol Efflux
Positive Regulation Of Hyaluronan Biosynthetic Process
Positive Regulation Of Protein Localization To Early Endosome
Positive Regulation Of Epithelial Tube Formation
Regulation Of Protein Localization To Cell Surface
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Peptide Metabolic Process
Anatomical Structure Morphogenesis
Protein Processing
Pathways
Platelet degranulation
Signaling by ERBB2
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
Signaling by ERBB4
SHC1 events in ERBB2 signaling
SHC1 events in ERBB2 signaling
PLCG1 events in ERBB2 signaling
PIP3 activates AKT signaling
Signaling by EGFR
Signaling by EGFR
GRB2 events in EGFR signaling
GAB1 signalosome
SHC1 events in EGFR signaling
EGFR downregulation
GRB2 events in ERBB2 signaling
PI3K events in ERBB2 signaling
EGFR interacts with phospholipase C-gamma
Constitutive Signaling by Aberrant PI3K in Cancer
Constitutive Signaling by EGFRvIII
Inhibition of Signaling by Overexpressed EGFR
RAF/MAP kinase cascade
ERBB2 Regulates Cell Motility
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
ERBB2 Activates PTK6 Signaling
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Downregulation of ERBB2 signaling
Extra-nuclear estrogen signaling
NOTCH3 Activation and Transmission of Signal to the Nucleus
Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Signaling by ERBB2 KD Mutants
Signaling by ERBB2 ECD mutants
Signaling by ERBB2 TMD/JMD mutants
Post-translational modification: synthesis of GPI-anchored proteins
Drugs
Sucralfate
Alpha-Aminobutyric Acid
Cholecystokinin
Tesevatinib
Diseases
GWAS
Albumin-globulin ratio (
29403010
)
Blood protein levels (
30072576
29875488
)
Glycated hemoglobin levels (
34059833
)
Hair morphology (
19896111
)
High light scatter reticulocyte count (
32888494
)
High light scatter reticulocyte percentage of red cells (
32888494
)
Lymphocyte counts (
32888494
)
Mean corpuscular hemoglobin concentration (
32888494
)
Mean corpuscular volume (
29403010
)
Mean spheric corpuscular volume (
32888494
)
Monocyte count (
32888494
)
Monocyte percentage of white cells (
32888494
)
Neutrophil percentage of white cells (
32888494
)
Non-albumin protein levels (
29403010
)
Platelet count (
29403010
33545615
32888494
27863252
)
Platelet distribution width (
32888494
)
Plateletcrit (
32888494
27863252
)
Reticulocyte count (
32888494
27863252
)
Reticulocyte fraction of red cells (
32888494
27863252
)
Spleen volume (
34128465
)
Waist-to-hip ratio adjusted for BMI (
28552196
)
Blood protein levels (
29875488
)
Coffee consumption (
31046077
)
Major depressive disorder (
20673876
)
Pneumoconiosis in silica exposure (
24986923
)
Refractive astigmatism (
30306274
)
Resting-state electroencephalogram vigilance (
29703947
)
Interacting Genes
14 interacting genes:
ADAM12
CPM
DUSP3
EGFR
ERBB2
ERBB3
GRB2
GRK2
LMNA
MGST1
NRG1
PIK3R1
PIK3R2
VTN
2 interacting genes:
EGF
HBA2
Entrez ID
1950
1368
HPRD ID
00578
00273
Ensembl ID
ENSG00000138798
ENSG00000135678
Uniprot IDs
P01133
P14384
PDB IDs
1IVO
1JL9
1NQL
1P9J
2KV4
3NJP
1UWY
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?