LPAR1 and ARHGEF11

Number of citations of the paper that reports this interaction (PubMedID 15755723)
44

Data Source:
HPRD (in vivo, in vitro)

		LPAR1	ARHGEF11
Description		lysophosphatidic acid receptor 1	Rho guanine nucleotide exchange factor 11
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GO Annotations	Cellular Component	Cytoplasm Endosome Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Endocytic Vesicle	Cytoplasm Cytosol Membrane
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding Lysophosphatidic Acid Binding Lysophosphatidic Acid Receptor Activity	G Protein-coupled Receptor Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Cell Shape Negative Regulation Of Neuron Projection Development Regulation Of Metabolic Process Neurogenesis Positive Regulation Of Rho Protein Signal Transduction Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAPK Cascade Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Positive Regulation Of Stress Fiber Assembly Cell Chemotaxis	Regulation Of Cell Growth Striated Muscle Contraction G Protein-coupled Receptor Signaling Pathway Rho Protein Signal Transduction Establishment Of Cell Polarity Actin Cytoskeleton Organization Positive Regulation Of Transcription, DNA-templated Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction
Pathways		G alpha (q) signalling events G alpha (i) signalling events Lysosphingolipid and LPA receptors	NRAGE signals death through JNK G alpha (12/13) signalling events Sema4D induced cell migration and growth-cone collapse RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle
Drugs
Diseases
GWAS		Birth weight ( 31043758 27680694) Brain morphology (MOSTest) ( 32665545) Central corneal thickness ( 32528159 31798171 29760442 30894546) Corneal structure ( 23291589) Cortical thickness ( 32963231) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Height ( 20881960 25282103 31562340) Monocyte count ( 28193307 29403010 32888494 28031487) Monocyte percentage of white cells ( 32888494) Neutrophil percentage of granulocytes ( 27863252) Offspring birth weight ( 31043758) Post bronchodilator FEV1 in COPD ( 26634245) Pursuit maintenance gain ( 29064472) Sum eosinophil basophil counts ( 27863252) White blood cell count (monocyte) ( 28158719) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chin dimples ( 27182965) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Heel bone mineral density ( 30598549) Height ( 31562340) Lymphocyte counts ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte percentage of white cells ( 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		7 interacting genes: ARHGEF11 ARHGEF12 DRD2 GIPC1 GNAI3 KRAS SLC9A3R2	16 interacting genes: ABCA1 CDC42 GNA12 GNA13 LPAR1 LPAR2 MAP1A MAP1B NEK2 PLXNB1 PLXNB2 PLXNB3 PTPRF RHOA RPS6KA1 SLC1A6
Entrez ID		1902	9826
HPRD ID		03790	09302
Ensembl ID		ENSG00000198121	ENSG00000132694
Uniprot IDs		Q5VZX0 Q92633	O15085
PDB IDs		4Z34 4Z35 4Z36	1HTJ 1XCG 2DLS 3KZ1 3T06 5E6P 5JHG 5JHH 5TYT
Enriched GO Terms of Interacting Partners?
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