E2F6 and PCGF6

Number of citations of the paper that reports this interaction (PubMedID 11171983)
96

Data Source:
HPRD (in vitro)

		E2F6	PCGF6
Description		E2F transcription factor 6	polycomb group ring finger 6
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm MLL1 Complex RNA Polymerase II Transcription Regulator Complex	Nucleus Nucleoplasm PcG Protein Complex PRC1 Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding Protein Dimerization Activity	Protein Binding Metal Ion Binding
	Biological Process	Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Histone H2A-K119 Monoubiquitination Negative Regulation Of Transcription, DNA-templated
Pathways		G1/S-Specific Transcription Transcriptional Regulation by E2F6	Transcriptional Regulation by E2F6
Drugs
Diseases
GWAS		Diisocyanate-induced asthma ( 25918132) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Sudden cardiac arrest ( 21658281)	Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (MOSTest) ( 32665545) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309) Schizophrenia ( 25056061 29483656 23974872)
Interacting Genes		29 interacting genes: APP ARAF BMI1 BRDT CENPU DNMT1 DNMT3L DNTTIP1 DRD2 E2F1 EPC1 EZH1 EZH2 HMG20B INO80B KRTAP10-7 MDN1 NFYA PCGF6 PIK3R3 RING1 RYBP SMARCA4 TFDP1 TFDP2 ZBTB17 ZBTB32 ZFPM2 ZMYND11	27 interacting genes: BMI1 CBX6 CBX7 CDK7 E2F6 EIF2B2 H3-4 KDM5D MAGEA1 MAGEC2 MAGEE2 MAGEL2 OGT PEX10 PNMA1 RAD18 RING1 RNF2 SS18L1 TRIM14 TRIM55 TRIM63 TULP3 UBE2D3 UBE2U USP2 USP21
Entrez ID		1876	84108
HPRD ID		04251	07427
Ensembl ID		ENSG00000169016	ENSG00000156374
Uniprot IDs		A0A0S2Z3K8 O75461 Q53YM3 Q6Q9Z5	Q9BYE7
PDB IDs			2DJB
Enriched GO Terms of Interacting Partners?
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