E2F5 and NSD3

		E2F5	NSD3
Description		E2F transcription factor 5	nuclear receptor binding SET domain protein 3
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GO Annotations	Cellular Component	Chromatin Fibrillar Center Nucleoplasm Nucleolus Intracellular Membrane-bounded Organelle RNA Polymerase II Transcription Regulator Complex	Chromatin Nucleus Nucleoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Protein Dimerization Activity	Protein Binding Histone-lysine N-methyltransferase Activity Metal Ion Binding Histone Methyltransferase Activity (H3-K36 Specific) Transcription Regulator Activator Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Cell Projection Organization Positive Regulation Of Transcription, DNA-templated Regulation Of Cell Cycle	Regulation Of Transcription, DNA-templated Histone H3-K36 Methylation Histone Methylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Histone H3-K36 Trimethylation
Pathways		Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 G0 and Early G1 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Cyclin E associated events during G1/S transition G1/S-Specific Transcription G1/S-Specific Transcription Cyclin D associated events in G1 Cyclin A:Cdk2-associated events at S phase entry	PKMTs methylate histone lysines
Drugs
Diseases
GWAS		Blood protein levels ( 28240269) Plasma amyloid beta peptide concentrations (ABx-40) ( 24535457)
Interacting Genes		9 interacting genes: CREBBP DNMT3L EP300 NSD3 RBL1 RBL2 SMAD3 TFDP1 XPO1	49 interacting genes: AKT1 AP3M2 ATM BCAR3 BMP8B CASP8 CBLC CBX3 CBX5 CDKN2A CHEK2 DAXX DOCK7 E2F5 ESR1 ETV3 ETV6 FGFR4 GLIS2 GLYR1 H1-1 H3-5 H3C1 H4C1 HOXC4 IVNS1ABP LSM1 MLLT6 MNDA MYC NFIC PAX2 PPM1D RB1CC1 SEPTIN6 SLU7 SOX3 SOX4 SPAG8 SQSTM1 STAC3 TCF3 TEAD2 TERT TGFB1 TRIM55 TRIM63 UBE2I ZNF557
Entrez ID		1875	54904
HPRD ID		02983	06155
Ensembl ID		ENSG00000133740	ENSG00000147548
Uniprot IDs		Q15329	Q9BZ95
PDB IDs		5TUV	2DAQ 2NCZ 2ND1 4GND 4GNE 4GNF 4GNG 4RXJ 5UPD 6CEN 6G24 6G25 6G27 6G29 6G2B 6G2C 6G2E 6G2F 6G2O 6G3P 6G3T 7CRP 7CRQ 7CRR
Enriched GO Terms of Interacting Partners?
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