ACAN and ADAMTS5

Number of citations of the paper that reports this interaction (PubMedID 11854269)
19

Data Source:
HPRD (in vivo)

		ACAN	ADAMTS5
Description		aggrecan	ADAM metallopeptidase with thrombospondin type 1 motif 5
Image
GO Annotations	Cellular Component	Extracellular Region Golgi Lumen Extracellular Matrix Lysosomal Lumen Collagen-containing Extracellular Matrix	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Collagen-containing Extracellular Matrix
	Molecular Function	Extracellular Matrix Structural Constituent Protein Binding Hyaluronic Acid Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance Carbohydrate Binding Metal Ion Binding	Endopeptidase Activity Metalloendopeptidase Activity Integrin Binding Protein Binding Heparin Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Extracellular Matrix Binding
	Biological Process	Skeletal System Development Proteolysis Cell Adhesion Central Nervous System Development	Proteolysis Myoblast Fusion Extracellular Matrix Disassembly Extracellular Matrix Organization Defense Response To Bacterium Tooth Eruption Negative Regulation Of Cold-induced Thermogenesis
Pathways		Degradation of the extracellular matrix Degradation of the extracellular matrix Keratan sulfate biosynthesis Keratan sulfate degradation ECM proteoglycans Defective CHST6 causes MCDC1 Defective ST3GAL3 causes MCT12 and EIEE15 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)	Degradation of the extracellular matrix Degradation of the extracellular matrix Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins
Drugs		Ilomastat	Batimastat (2R)-N~4~-hydroxy-2-(3-hydroxybenzyl)-N~1~-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]butanediamide N-hydroxy-4-({4-[4-(trifluoromethyl)phenoxy]phenyl}sulfonyl)tetrahydro-2H-pyran-4-carboxamide
Diseases
GWAS		Age-related hearing impairment ( 27764096) Appendicular lean mass ( 33097823) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body size at age 10 ( 32376654) Dupuytren's disease ( 28886342) Height ( 21998595 28552196 20881960 25282103 25133637 25429064 23563607 31562340 28270201 18391952 33713608) Hip circumference adjusted for BMI ( 34021172 25673412) Infant length ( 25281659) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 34021172 25673412 28448500)	Blood protein levels ( 30072576 29875488 28240269) Dialysis-related mortality ( 21546767) Diastolic blood pressure ( 29343252) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Height ( 31562340) Plasma anti-thyroglobulin and anti-thyroid peroxidase levels (bivariate analysis) ( 29678681) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		23 interacting genes: ADAMTS1 ADAMTS4 ADAMTS5 BLM CTSB FBLN1 FBLN2 HAPLN1 IDH2 LUM MAN2A2 MMP1 MMP14 MMP19 MMP2 MMP20 MMP3 MMP8 PTPRF SLCO3A1 STARD5 TNFAIP6 TNR	2 interacting genes: ACAN MMP13
Entrez ID		176	11096
HPRD ID		01123	05420
Ensembl ID		ENSG00000157766	ENSG00000154736
Uniprot IDs		A0A5K1VW97 P16112	Q9UNA0
PDB IDs		4MD4	2RJQ 3B8Z 3HY7 3HY9 3HYG 3LJT
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?