DLG2 and SCN4A

Number of citations of the paper that reports this interaction (PubMedID 16637659)
29

Data Source:
HPRD (in vitro)

		DLG2	SCN4A
Description		discs large MAGUK scaffold protein 2	sodium voltage-gated channel alpha subunit 4
Image
GO Annotations	Cellular Component	Cytosol Plasma Membrane Postsynaptic Density Membrane Basolateral Plasma Membrane Cell Junction Neuromuscular Junction Neuron Projection Perikaryon Juxtaparanode Region Of Axon Postsynaptic Density Membrane Axon Cytoplasm	Voltage-gated Sodium Channel Complex Integral Component Of Plasma Membrane Axon
	Molecular Function	Guanylate Kinase Activity Protein Binding Kinase Binding	Voltage-gated Ion Channel Activity Voltage-gated Sodium Channel Activity Protein Binding
	Biological Process	Chemical Synaptic Transmission Embryo Development Cellular Response To Potassium Ion Receptor Clustering Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity GMP Metabolic Process GDP Metabolic Process Receptor Localization To Synapse Cell-cell Adhesion Anterograde Axonal Protein Transport Retrograde Axonal Protein Transport	Sodium Ion Transport Muscle Contraction Neuronal Action Potential Regulation Of Ion Transmembrane Transport Sodium Ion Transmembrane Transport Membrane Depolarization During Action Potential Regulation Of Skeletal Muscle Contraction By Action Potential
Pathways		Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor RAF/MAP kinase cascade Neurexins and neuroligins Neurexins and neuroligins Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation	Interaction between L1 and Ankyrins Phase 0 - rapid depolarisation
Drugs			Ranolazine Topiramate Lidocaine Valproic acid Lamotrigine Carbamazepine Oxcarbazepine Propofol Cocaine Zonisamide Promethazine Flecainide Brivaracetam Tetracaine Amylocaine Propoxycaine Pramocaine Pentoxyverine Parachlorophenol Dichlorobenzyl alcohol Bioallethrin Fish oil
Diseases
GWAS		Adult body size ( 32376654) Age at first sexual intercourse ( 27089180) Attention function in attention deficit hyperactive disorder ( 26174813) BMI at adiposity rebound ( 31840077) Body fat mass ( 28552196) Body mass index ( 28552196) Brain morphology (MOSTest) ( 32665545) Cerebrospinal fluid t-tau:AB1-42 ratio ( 28641921) Chronic obstructive pulmonary disease ( 25584925) Chronic periodontitis ( 25008200) Estrogen level change in anastrozole-treated breast cancer ( 32701512) Familial squamous cell lung carcinoma ( 29924316) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Height ( 28552196) Influenza A (H1N1) infection ( 26379185) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Lung adenocarcinoma (survival time) in never smokers ( 32699080) Migraine without aura ( 28952330) Mild influenza (H1N1) infection ( 26379185) Modic changes ( 30808802) Myopia ( 27182965) Nicotine dependence symptom count ( 25555482) Obesity-related traits ( 23251661) Oily fish consumption ( 32066663) Pallidum volume ( 31530798) Parkinson's disease ( 25064009 32201043 28892059 28011712 17052657 32310270) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Phospholipid levels (plasma) ( 22359512) Pork consumption ( 32066663) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Protein quantitative trait loci ( 18464913) Putamen volume ( 29147026) Refractive error ( 32231278) Response to fenofibrate (triglyceride levels) ( 27002377) Response to TNF inhibitor in rheumatoid arthritis (change in swollen 28-joint count) ( 30166627) Schizophrenia ( 30285260) Schizophrenia x sex interaction ( 34099189) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Subcortical brain region volumes ( 25607358) Trunk fat mass ( 28552196) Type 2 diabetes ( 31049640) Urate levels in overweight individuals ( 25811787) Weight ( 28552196) Wilms tumor ( 22544364)	Height ( 28552196 31562340) Hip circumference adjusted for BMI ( 34021172)
Interacting Genes		53 interacting genes: ABCA1 ALK AOAH ATP2B2 ATP2B4 CACNG2 CNKSR2 CRIPT DLG1 DLG4 DLGAP1 DLGAP2 DLGAP3 ERBB4 FA2H FASLG FZD1 FZD4 FZD7 GLS2 GRID1 GRID2 GRIN1 GRIN2A GRIN2B GRIN2D GUCY1A2 KCNA4 KCNJ12 KCNJ2 KCNJ4 KDELR1 KHDRBS1 KIF1B LIN7A LRP2 MAP1A MAPK12 NLGN1 NLGN2 NLGN3 NOS1 PLEKHA2 PPIL4 RNASE2 RPF2 RPS8 SCN4A SCN5A SEMA4C SERPINB13 VTN WNT3A	10 interacting genes: CALM1 DLG1 DLG2 DLG3 ERBIN PATJ SLC9A3R1 SNTA1 SNTB1 SNTB2
Entrez ID		1740	6329
HPRD ID		04663	04912
Ensembl ID		ENSG00000150672	ENSG00000007314
Uniprot IDs		B7Z2T4 Q15700	P35499
PDB IDs		2BYG 2HE2	6AGF 6MBA 6MC9
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?