DLAT and PDK3

Number of citations of the paper that reports this interaction (PubMedID 28514442)
406

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		DLAT	PDK3
Description		dihydrolipoamide S-acetyltransferase	pyruvate dehydrogenase kinase 3
Image
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Mitochondrial Pyruvate Dehydrogenase Complex Intracellular Membrane-bounded Organelle Pyruvate Dehydrogenase Complex	Nucleolus Mitochondrion Mitochondrial Matrix
	Molecular Function	Dihydrolipoyllysine-residue Acetyltransferase Activity Protein Binding Pyruvate Dehydrogenase (NAD+) Activity Identical Protein Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Pyruvate Dehydrogenase (acetyl-transferring) Kinase Activity Protein Binding ATP Binding
	Biological Process	Glucose Metabolic Process Acetyl-CoA Biosynthetic Process From Pyruvate Tricarboxylic Acid Cycle Sleep	Glucose Metabolic Process Protein Phosphorylation Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Regulation Of Glucose Metabolic Process Peptidyl-serine Phosphorylation Peroxisome Proliferator Activated Receptor Signaling Pathway Cellular Response To Glucose Stimulus Cellular Response To Fatty Acid Hypoxia-inducible Factor-1alpha Signaling Pathway Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Regulation of pyruvate dehydrogenase (PDH) complex Glyoxylate metabolism and glycine degradation Signaling by Retinoic Acid Pyruvate metabolism	Regulation of pyruvate dehydrogenase (PDH) complex Signaling by Retinoic Acid
Drugs		NADH Radicicol Dihydrolipoic Acid	Radicicol Dihydrolipoic Acid
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Malaria ( 31844061)
Interacting Genes		8 interacting genes: HMGB1 PDHA1 PDHX PDK1 PDK2 PDK3 PDK4 PRKD3	4 interacting genes: APP DLAT EGFR PDHA1
Entrez ID		1737	5165
HPRD ID		10578	03956
Ensembl ID		ENSG00000150768	ENSG00000067992
Uniprot IDs		P10515 Q86YI5	Q15120
PDB IDs		1FYC 1Y8N 1Y8O 1Y8P 2DNE 2PNR 2Q8I 3B8K 3CRK 3CRL 6CT0 6H55	1Y8N 1Y8O 1Y8P 2PNR 2Q8I
Enriched GO Terms of Interacting Partners?
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