SGMS2 and CTSA

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		SGMS2	CTSA
Description		sphingomyelin synthase 2	cathepsin A
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Golgi Membrane Integral Component Of Endoplasmic Reticulum Membrane	Extracellular Region Lysosome Endoplasmic Reticulum Membrane Azurophil Granule Lumen Lysosomal Lumen Intracellular Membrane-bounded Organelle Extracellular Exosome Lumenal Side Of Lysosomal Membrane
	Molecular Function	Ceramide Phosphoethanolamine Synthase Activity Protein Binding Kinase Activity Sphingomyelin Synthase Activity Ceramide Cholinephosphotransferase Activity	Carboxypeptidase Activity Serine-type Carboxypeptidase Activity Enzyme Activator Activity
	Biological Process	Sphingomyelin Biosynthetic Process Phosphorylation Sphingolipid Biosynthetic Process Regulation Of Bone Mineralization Ceramide Biosynthetic Process Ceramide Phosphoethanolamine Biosynthetic Process	Proteolysis Intracellular Protein Transport Regulation Of Protein Stability Regulation Of Catalytic Activity Regulation Of Chaperone-mediated Autophagy Negative Regulation Of Chaperone-mediated Autophagy
Pathways		Sphingolipid de novo biosynthesis	Glycosphingolipid metabolism MHC class II antigen presentation Sialic acid metabolism Defective NEU1 causes sialidosis Neutrophil degranulation
Drugs
Diseases
GWAS		Metabolite levels ( 23823483) Monoclonal gammopathy of undetermined significance ( 30737484) Obsessive-compulsive traits ( 33531474)
Interacting Genes		6 interacting genes: CTSA GPX8 LMNA LPAR3 VAMP1 ZFPL1	45 interacting genes: AHNAK2 AQP2 AQP6 ARL13B ASPH BSND CD79A COQ9 CPLX4 CREB3L1 CSPG5 ERGIC3 FAM209A FKBP7 FNDC9 GLB1 GORAB HIBADH LAMP2 LMNA LTB4R2 MFSD14B MGST3 MUC1 MYG1 NEU1 PSCA REEP4 RHBDD1 RNF122 SAR1A SGMS2 SIGLEC12 SLC18A1 SLC30A2 SPN SSMEM1 STX2 THAP4 TMEM139 TMEM154 TMEM237 TMEM31 TMEM35A TMX2
Entrez ID		166929	5476
HPRD ID		11323	02020
Ensembl ID		ENSG00000164023	ENSG00000064601
Uniprot IDs		A0A024RDH4 Q8NHU3	B4E324 P10619 X6R5C5 X6R8A1
PDB IDs			1IVY 3BP4 3BP7 3BXN 4AZ0 4AZ3 4CI9 4CIA 4CIB 4MWS 4MWT 6WIA
Enriched GO Terms of Interacting Partners?
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