TLE5 and KRT40

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid, two hybrid)

		TLE5	KRT40
Description		TLE family member 5, transcriptional modulator	keratin 40
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Transcription Regulator Complex	Cytosol Intermediate Filament
	Molecular Function	Transcription Corepressor Activity Protein Binding	Structural Molecule Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Multicellular Organism Development Animal Organ Morphogenesis Negative Regulation Of Gene Expression Wnt Signaling Pathway Cellular Response To Extracellular Stimulus Negative Regulation Of Protein Binding Regulation Of Growth Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Response To Cytokine Stimulus Response To Interleukin-1 Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Anoikis
Pathways		Repression of WNT target genes	Keratinization Formation of the cornified envelope
Drugs
Diseases
GWAS			Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223)
Interacting Genes		370 interacting genes: ABI2 AEN AGR2 AKAP8L AMH ANAPC11 ANKRD11 AR ARHGAP32 ARX ASB3 ATN1 ATP6V0D1 BAG4 BAHD1 BCL6 BHLHE40 BIRC7 BPIFA1 BYSL C10orf55 C11orf1 C14orf119 C19orf54 C1orf109 C1orf216 C1orf94 C2CD6 C7orf57 CABP2 CABP4 CABP5 CALCOCO2 CAPN1 CARD9 CCDC120 CCDC57 CCL7 CCNJL CCNK CCNO CFAP206 CIB3 CLIC3 CLIP3 CNFN COA7 CPSF7 CRACR2A CRX CSNK2A1 CSTF2 CSTF2T CT55 CTBP2 CYSRT1 DAZAP2 DCUN1D1 DDX6 DGCR6 DIP2A DMRT2 DMRT3 DMRTB1 DNMT3L DOK6 DVL2 DVL3 DYDC1 EAF1 EAF2 EFEMP2 EFHC1 EIF1AD EIF4E2 ERF EXOSC5 EYA2 FAM124A FAM124B FAM168B FAM214B FAM217B FAM90A1 FANCG FBF1 FBLN1 FCHSD2 FHL3 FOSB FOXD2 FOXN1 FOXP2 FRS3 FSD2 FXR1 FXR2 GABARAP GATA1 GCC1 GEM GFAP GFI1B GIGYF1 GLIS2 GLRX3 GOLGA2 GOLGA6L9 GORASP2 GPANK1 GPATCH2L GRAP2 GRB2 GRN GTF2E1 GYS1 HCN2 HDAC4 HDHD3 HELT HEXIM2 HGS HHEX HMGB1 HNF1A HNRNPF HNRNPH2 HNRNPK HNRNPLL HOMEZ HOXA1 HOXB5 HOXC8 HOXC9 IKZF3 INO80B INO80E INPP5J IRX2 IRX6 KANK2 KDM1A KIFC3 KLF1 KLF4 KLHDC7B KRT13 KRT15 KRT31 KRT34 KRT35 KRT40 KRTAP10-11 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-2 KRTAP13-2 KRTAP13-3 KRTAP17-1 KRTAP19-5 KRTAP19-7 KRTAP6-2 KRTAP6-3 KRTAP7-1 KRTAP8-1 L3MBTL2 LDLR LDOC1 LENG8 LHX3 LINC00526 LMO1 LMO2 LMO4 LSM2 LZTS2 MAGOHB MAPK1 MAPK14 MAPRE3 MBNL1 MCRS1 MDFI MED12L MED25 MED31 MED4 MEIS3 MFAP1 MIA2 MIIP MKRN3 MLH1 MLLT6 MLX MORF4L1 MORF4L2 MSS51 MSX1 MSX2 MTUS2 MVP MYF5 MYH7B MYO15B MYOG NAB2 NAF1 NBPF19 NCDN NDOR1 NDUFB7 NEK6 NLGN3 NOTCH2NLA NTAQ1 NUDT22 NUTF2 NUTM1 OLIG3 OSGIN1 OXER1 P4HA3 PARVG PATZ1 PAX8 PAX9 PCBP1 PCSK5 PFDN5 PHF1 PHKB PICK1 PITX1 PITX2 PLAGL1 POLR1C POU2F1 PPP1R16A PPP1R16B PRDM1 PRDM14 PRDM6 PRKAA1 PRKAA2 PRKAB2 PROP1 PRPF31 PRR3 PRR35 PSMB1 PSMB4 PSMF1 PTRH2 QARS1 RAD51D RBM10 RBPMS REL RELA RFX6 RHOXF2 RIBC1 RIMBP3 RIPPLY1 RNF31 RORB RPL18A RUNX1 RUSC1 SAT1 SCNM1 SDCBP SERTAD3 SET SF3B4 SH2B2 SH3GL3 SHFL SHISA6 SIX1 SIX2 SIX3 SIX6 SKIL SMAD3 SMAD4 SMARCB1 SMARCD1 SNCAIP SNRPA SNRPC SOHLH1 SOX5 SPATA25 SPG21 SRPK2 SSC4D STK16 STX11 SUFU SUPT5H TBX3 TBX6 TCEANC TCF4 TCF7L2 TEAD4 TENT5B TEX37 TFAP2D THAP7 TIGD3 TMCC2 TNS2 TOX3 TRAF1 TRAF2 TRIB3 TRIM26 TRIM27 TRIM41 TRIP6 TRMT2A TSC1 TSC22D4 TSEN15 TSGA10 TSGA10IP TSSK3 TTC23 U2AF2 UBAP2 UBE2H UBL5 UBXN11 USP2 USP54 VEZF1 VGLL1 VIM VPS37B VPS37C YPEL3 YTHDF1 ZBTB16 ZBTB24 ZBTB47 ZFHX3 ZGPAT ZIC1 ZMYND12 ZNF330 ZNF34 ZNF383 ZNF408 ZNF414 ZNF417 ZNF467 ZNF48 ZNF503 ZNF524 ZNF576 ZNF688 ZNF792 ZNF835 ZRANB1	381 interacting genes: ACSF3 ADAMTS1 ADAMTSL3 AEN AGXT AKAP17A ALDH3B1 ANKRD36BP1 AP1M1 AQP1 AQP5 ARID5A ARMC7 ARSI ASMTL ATPAF2 AVPI1 AXIN1 BAHD1 BARD1 BCAS2 BEX2 BMS1P1 BRME1 BYSL C10orf62 C11orf87 C19orf73 C1orf109 C1orf216 C22orf46 C2CD6 C2orf68 C4orf45 C5orf60 C6orf226 C8orf48 CA6 CARD9 CATIP CBX8 CCDC112 CCDC116 CCDC120 CCDC146 CCDC185 CCDC198 CCDC26 CCDC93 CCER1 CCHCR1 CCNG1 CD33 CDC20B CDK18 CDK5R1 CELA2B CEP57 CEP57L1 CFAP206 CHCHD2 CHCHD3 CHIC2 CLEC18A CNNM3 CNTF COL8A1 COMT COX5A CREB5 CRY2 CTSZ CWF19L2 CYCS CYTH4 DAAM2 DCDC2B DCX DDX6 DHX57 DLGAP2 DMRT3 DOCK2 DOCK8 DTNB EIF4E2 ELOA ENKD1 EXOC3-AS1 FADS2 FAM107A FAM124B FAM214A FAM27E3 FAM71C FAM74A4 FAM90A1 FARS2 FASLG FBF1 FBXL18 FBXO34 FBXW5 FEZF1 FKBP1B FNDC11 FOXB1 FRG1 GAD1 GADD45GIP1 GATA2 GATAD2A GEM GFOD1 GGN GLIDR GNAI2 GNE GNG5 GOLGA6L2 GPATCH2L GTF3C5 GUCD1 HAPLN2 HAUS1 HBA2 HBZ HCK HDAC4 HGS HNRNPLL HOXA1 HOXB9 HOXC8 HSD3B7 HSF4 HSPA12B HSPD1 ING5 INO80B INPP5D IQUB ISCU ITGB4 ITGB5 JOSD1 KANK2 KAT5 KCTD9 KDM1A KIFC3 KLHL38 KPNA2 KRT2 KRT20 KRT4 KRT5 KRT6A KRT6B KRT6C KRT71 KRT72 KRT75 KRT76 KRT8 KRT81 KRT82 KRT83 KRT85 KRT86 LAGE3 LCE3E LENG1 LHX4 LIMS2 LIN37 LINC00636 LINC01588 LMF2 LMO1 LMO2 LMO4 LRCH4 MAB21L2 MAGOHB MAPKBP1 MARK4 MED8 METTL17 MFAP1 MID2 MOB3C MOBP MOS MRPL11 MRRF MSRB3 MTA1 MXI1 MYPOP NAB2 NAPRT NDEL1 NEK6 NFKBID NINJ1 NOL4L-DT NPBWR2 NPPB NR1D2 NXF1 ODAD4 OIP5 OPCML OTUB2 PDLIM5 PGLS PHF1 PHF21A PHLDA1 PIGS PIMREG PIN1 PKD2 POLDIP3 POLL POM121L8P POP5 PPP1R18 PRAM1 PRKAA1 PRKAB2 PRPF18 PRPF31 PSMA1 PSMB1 PSMC5 PTGER3 PTPMT1 PXMP2 QPRT RAB3IL1 RAB3IP RAC1 RASSF5 RBM41 RCOR3 RECK RGS8 RNF213 RNF6 RPL11 RSPH14 RTP5 RWDD2B RXRB SCAND1 SCOC SEMA4C SETD5 SH2D4A SHC3 SHFL SIRPA SLC23A1 SLC25A10 SLIRP SLU7 SMARCE1 SMCO4 SNAI1 SNHG11 SNRPB SNW1 SPATA24 SPATC1L SPEF1 SPG7 SRSF2 SSX2 SSX2IP SUOX SYT6 TACO1 TAPBPL TBC1D16 TBC1D21 TBC1D22B TCEA2 TCEANC TCHP TEAD4 THAP7 TIE1 TLE5 TMEM231 TMEM241 TMSB4X TNIP3 TNNT1 TRAF4 TRIM42 TROAP TRPV6 TSC22D4 TSGA10IP TSHZ3 TTC23 TTC9C TTLL10 TXLNA TXN2 TXNDC5 TYK2 TYRO3 UACA UBASH3A UCMA USHBP1 USP2 USP21 UTP14C UTP23 UXT VEZF1 WDR25 WT1 WT1-AS ZBTB16 ZBTB24 ZBTB38 ZBTB42 ZC2HC1C ZFHX3 ZFP1 ZFP2 ZFP69B ZFYVE21 ZFYVE26 ZGPAT ZMAT2 ZNF101 ZNF124 ZNF138 ZNF165 ZNF17 ZNF20 ZNF202 ZNF230 ZNF250 ZNF26 ZNF266 ZNF286A ZNF317 ZNF319 ZNF329 ZNF337 ZNF408 ZNF410 ZNF417 ZNF438 ZNF439 ZNF446 ZNF488 ZNF490 ZNF564 ZNF569 ZNF575 ZNF580 ZNF581 ZNF587 ZNF625 ZNF655 ZNF688 ZNF697 ZNF702P ZNF76 ZNF792 ZNF844 ZNRF2P1 ZSCAN21
Entrez ID		166	125115
HPRD ID		02556	08304
Ensembl ID		ENSG00000104964	ENSG00000204889
Uniprot IDs		Q08117 Q8WY48	Q6A162
PDB IDs
Enriched GO Terms of Interacting Partners?
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