DDX6 and ZRANB1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		DDX6	ZRANB1
Description		DEAD-box helicase 6	zinc finger RANBP2-type containing 1
Image
GO Annotations	Cellular Component	Heterochromatin P-body Outer Dense Fiber Nucleus Nucleolus Cytoplasm Mitochondrion Cytosol Adherens Junction Cytoplasmic Stress Granule Membrane RISC Complex Chromatoid Body Cytoplasmic Ribonucleoprotein Granule Perinuclear Region Of Cytoplasm Concave Side Of Sperm Head Sperm Annulus	Nucleus Nucleoplasm Cytoplasm Cytosol Intracellular Membrane-bounded Organelle
	Molecular Function	RNA Binding RNA Helicase Activity MRNA Binding Helicase Activity Protein Binding ATP Binding ATP Hydrolysis Activity Protein Domain Specific Binding Cadherin Binding	Thiol-dependent Deubiquitinase Protein Binding Metal Ion Binding K63-linked Polyubiquitin Modification-dependent Protein Binding
	Biological Process	Negative Regulation Of Translation Viral RNA Genome Packaging Stem Cell Population Maintenance P-body Assembly Stress Granule Assembly Negative Regulation Of Neuron Differentiation Spermatid Differentiation Positive Regulation Of MiRNA Mediated Inhibition Of Translation	Cytoskeleton Organization Wnt Signaling Pathway Cell Migration Regulation Of Cell Morphogenesis Positive Regulation Of Wnt Signaling Pathway Protein K29-linked Deubiquitination Protein K63-linked Deubiquitination Protein Deubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Protein K33-linked Deubiquitination
Pathways		mRNA decay by 5' to 3' exoribonuclease	Degradation of beta-catenin by the destruction complex Ovarian tumor domain proteases
Drugs		D-tartaric acid
Diseases
GWAS		Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Allergy ( 27182965) Asthma ( 31959851 30929738 34103634 31619474) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433 30929738) Asthma onset (childhood vs adult) ( 30929738) Autoimmune traits (pleiotropy) ( 30572963) Blood protein levels ( 30072576) Celiac disease ( 22057235) Celiac disease and Rheumatoid arthritis ( 26546613) Celiac disease or Rheumatoid arthritis ( 21383967) Diffuse cutaneous systemic sclerosis ( 24387989) Height ( 25429064) Hip minimal joint space width ( 27701424) Monocyte percentage of white cells ( 32888494) Multiple sclerosis ( 31604244) Non-albumin protein levels ( 29403010) Primary biliary cholangitis ( 28425483) Primary biliary cirrhosis ( 22961000) Refractive error ( 32231278) Rheumatoid arthritis ( 23143596) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Systemic lupus erythematosus ( 28714469 19838195) Systemic sclerosis ( 24387989 31672989) Vitiligo ( 22951725)	Blood urea nitrogen levels ( 31152163) Creatine kinase levels ( 29403010) Height ( 25429064 31562340) Lung cancer ( 34062886)
Interacting Genes		77 interacting genes: BEGAIN BEND7 BHLHB9 BIRC7 CALCOCO2 CCDC136 CCDC14 CEP70 CEP76 CNKSR3 CNOT1 DDX17 DES DISC1 DNAAF11 EDC3 EFHC2 ENTR1 FCHO1 GIGYF1 GOLGA2 HOOK2 IK IKZF1 INKA1 JAKMIP1 JUP KLC4 KRT34 KRT40 KRTAP10-3 KRTAP10-8 LZTS1 MAGED1 MESD MTUS2 NAB2 NONO PAK5 PDLIM7 PICK1 PNMA5 POU6F2 PRDM16 PRPH RAPGEF3 RBM11 RBM14 REL RO60 RUNDC3A SCYL1 SHMT1 SIPA1L2 SLAIN1 SORBS3 SPATA6 SRPK2 STAT1 TCF12 TCF4 TLE5 TP53BP2 TRAF2 TRIM27 TRIM37 TRIM54 U2AF2 USH1G VPS52 ZBTB10 ZBTB14 ZBTB43 ZBTB8A ZC2HC1C ZNF24 ZRANB1	153 interacting genes: AKT1 ANKRD11 AP1M1 ARHGEF5 ARRDC2 ARRDC3 BAHD1 BRD1 BYSL C1orf35 CARD9 CBX7 CBX8 CCDC120 CCDC13 CCDC185 CCDC187 CCNL1 CDC45 CDC5L CDK18 CDKL3 CNNM3 CORO7 CPNE7 CSNK1A1 CWF19L2 DCX DDX6 DNAJB13 DTNB DUSP13 EHHADH EIF3D ENKD1 ERF FAIM FAM124B FAM161A FAM161B FAM214B FAM50B FARS2 FNDC11 GADD45GIP1 GAS2L2 GEM GLIS2 GPANK1 GPKOW HOXB5 HOXC8 IL16 INO80B IP6K3 IQUB JRK KANK2 KIF9 KIFC3 LENG1 LMO3 LNX1 MAGEB4 MAGOH MCRS1 METAP1 METTL21A MFAP1 MID2 MPPED1 MYEF2 NEK6 NUDT16L1 NUDT21 PBLD PHF1 PHF19 PKN1 PLEKHN1 PNMA5 POLDIP3 POLL POLR1C PPP1R18 PRPF18 PRPF3 PRPF31 PSPC1 QARS1 RAPGEF3 RASAL3 RHOBTB3 RNPS1 SDCBP SNCA STAMBPL1 STK19 SUV39H1 SYT17 SYTL4 TBC1D3 TBC1D30 TBC1D3B TBC1D3C TBC1D3G TBC1D3K TCEA2 TCEANC THAP7 TIE1 TLE5 TNS4 TOLLIP TRAF3IP3 TRAF4 TRAF6 TRAPPC2 TRAPPC2B TSGA10IP TSPYL4 TSTD2 TWIST1 UBASH3A UBC UBE2S USP2 UVRAG VAV3 VEZF1 WT1 XRCC5 ZBTB24 ZBTB47 ZNF124 ZNF17 ZNF250 ZNF408 ZNF417 ZNF438 ZNF490 ZNF497 ZNF552 ZNF575 ZNF581 ZNF587 ZNF599 ZNF629 ZNF648 ZNF764 ZNF775 ZNF792 ZNF837
Entrez ID		1656	54764
HPRD ID		02638	11738
Ensembl ID		ENSG00000110367	ENSG00000019995
Uniprot IDs		B2R858 P26196	Q9UGI0
PDB IDs		1VEC 2WAX 2WAY 4CRW 4CT4 4CT5 5ANR 6F9S 6S8S	3ZRH 5AF6
Enriched GO Terms of Interacting Partners?
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