DDOST and STING1

Number of citations of the paper that reports this interaction (PubMedID 21903422)
143

Data Source:
BioGRID (pull down)

		DDOST	STING1
Description		dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	stimulator of interferon response cGAMP interactor 1
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GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Oligosaccharyltransferase Complex Membrane Integral Component Of Membrane Azurophil Granule Membrane Intracellular Membrane-bounded Organelle	Autophagosome Membrane Nucleoplasm Mitochondrial Outer Membrane Endosome Autophagosome Peroxisome Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Integral Component Of Endoplasmic Reticulum Membrane Cytoplasmic Vesicle Membrane Secretory Granule Membrane Perinuclear Region Of Cytoplasm Integral Component Of Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Membrane
	Molecular Function	Protein Binding Enzyme Activator Activity	Protein Binding Transcription Factor Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Cyclic-di-GMP Binding Identical Protein Binding Protein Homodimerization Activity 2',3'-cyclic GMP-AMP Binding
	Biological Process	Protein Glycosylation Protein N-linked Glycosylation Protein N-linked Glycosylation Via Asparagine Regulation Of Protein Stability Response To Cytokine T Cell Activation Regulation Of Catalytic Activity	Autophagosome Assembly Activation Of Innate Immune Response Positive Regulation Of Defense Response To Virus By Host Positive Regulation Of Macroautophagy Positive Regulation Of Protein Binding Positive Regulation Of Type I Interferon Production Positive Regulation Of Interferon-beta Production Cellular Response To Interferon-beta Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Inflammatory Response Positive Regulation Of DNA-binding Transcription Factor Activity Protein Complex Oligomerization Defense Response To Virus Reticulophagy Cellular Response To Exogenous DsRNA Cellular Response To Organic Cyclic Compound
Pathways		SRP-dependent cotranslational protein targeting to membrane Asparagine N-linked glycosylation Neutrophil degranulation Advanced glycosylation endproduct receptor signaling Maturation of spike protein	STING mediated induction of host immune responses Regulation of innate immune responses to cytosolic DNA STAT6-mediated induction of chemokines IRF3-mediated induction of type I IFN Neutrophil degranulation
Drugs
Diseases
GWAS		Proportion of activated microglia (inferior temporal cortex) ( 30679421)
Interacting Genes		6 interacting genes: LTB4R2 MAPK6 NXT1 PTEN SRSF11 STING1	27 interacting genes: CCDC47 CCDC50 CMTM5 DDOST IFI16 IRAK1 LEPROTL1 LTN1 MBOAT7 MUL1 MYSM1 PLLP REEP6 RNF115 RNF26 SGPL1 SMIM1 STT3A STX5 SURF4 TECR TMEM100 TRIM32 USP20 USP35 USP49 YIPF2
Entrez ID		1650	340061
HPRD ID		03728	14173
Ensembl ID		ENSG00000244038	ENSG00000184584
Uniprot IDs		A0A024RAD5 P39656	J3QTB1 Q86WV6 V5V0K2
PDB IDs		6S7O 6S7T	4EF4 4EF5 4EMT 4EMU 4F5D 4F5E 4F5W 4F5Y 4F9E 4F9G 4KSY 4LOH 4LOI 4QXO 4QXP 4QXQ 4QXR 5BQX 5JEJ 6CFF 6CY7 6DNK 6DXG 6DXL 6MX0 6MX3 6MXE 6NT5 6O8B 6O8C 6RM0 6S26 6S27 6S86 6UKM 6UKU 6UKV 6UKW 6UKX 6UKY 6UKZ 6UL0 6XF3 6XF4 6XNP
Enriched GO Terms of Interacting Partners?
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