DDC and ATF6

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		DDC	ATF6
Description		dopa decarboxylase	activating transcription factor 6
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Synaptic Vesicle Axon Neuronal Cell Body Extracellular Exosome	Golgi Membrane Chromatin Nucleus Nuclear Envelope Nucleoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane Integral Component Of Endoplasmic Reticulum Membrane
	Molecular Function	Aromatic-L-amino-acid Decarboxylase Activity Protein Binding Amino Acid Binding Carboxy-lyase Activity Enzyme Binding Protein Domain Specific Binding Pyridoxal Phosphate Binding 5-hydroxy-L-tryptophan Decarboxylase Activity L-dopa Decarboxylase Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Ubiquitin Protein Ligase Binding CAMP Response Element Binding Identical Protein Binding Sequence-specific DNA Binding Protein Heterodimerization Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Cellular Amino Acid Metabolic Process Catecholamine Metabolic Process Circadian Rhythm Multicellular Organism Aging Aminergic Neurotransmitter Loading Into Synaptic Vesicle Isoquinoline Alkaloid Metabolic Process Dopamine Biosynthetic Process Serotonin Biosynthetic Process Response To Pyrethroid Phytoalexin Metabolic Process Cellular Response To Alkaloid Cellular Response To Growth Factor Stimulus Cellular Response To Xenobiotic Stimulus	Eye Development Regulation Of Transcription By RNA Polymerase II Protein Folding Signal Transduction Visual Perception Positive Regulation Of Autophagy Endoplasmic Reticulum Unfolded Protein Response ATF6-mediated Unfolded Protein Response Positive Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of ATF6-mediated Unfolded Protein Response Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress
Pathways		Catecholamine biosynthesis Serotonin and melatonin biosynthesis	ATF4 activates genes in response to endoplasmic reticulum stress ATF6 (ATF6-alpha) activates chaperones ATF6 (ATF6-alpha) activates chaperone genes ATF6 (ATF6-alpha) activates chaperone genes
Drugs		Pyridoxal phosphate Carbidopa Methyldopa Benserazide	Pseudoephedrine
Diseases
GWAS		Acute lymphoblastic leukemia (childhood) ( 22076464 23512250 19684603) Adult body size ( 32376654) Blood metabolite ratios ( 24816252) Body mass index ( 26426971 25673413) Body mass index (age <50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Chronotype ( 30696823) Malaria ( 19465909) Morning person ( 30696823) Schizophrenia (treatment resistant) ( 25223841) Serum metabolite levels ( 33031748)	Chronic bronchitis in chronic obstructive pulmonary disease ( 25241909) Parkinson's disease (age of onset) ( 19772629) Systemic sclerosis ( 30247649)
Interacting Genes		3 interacting genes: AR ATF6 RELA	16 interacting genes: APP ATF6B BPGM CREB1 CREB3L3 DAPK1 DDC GTF2I MAGI1 NFYA NFYC NNMT SRF TNFRSF1A XBP1 YY1
Entrez ID		1644	22926
HPRD ID		00145	16118
Ensembl ID		ENSG00000132437	ENSG00000118217
Uniprot IDs		A0A087WV24 A0A0S2Z3N4 P20711 Q53Y41	A8K383 P18850
PDB IDs		3RBF 3RBL 3RCH
Enriched GO Terms of Interacting Partners?
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