DCX and PAFAH1B1

Number of citations of the paper that reports this interaction (PubMedID 11001923)
40

Data Source:
HPRD (in vitro, in vivo)

		DCX	PAFAH1B1
Description		doublecortin	platelet activating factor acetylhydrolase 1b regulatory subunit 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Cytoskeleton Microtubule Microtubule Associated Complex Axoneme Neuron Projection	Astral Microtubule Kinetochore Nuclear Envelope Centrosome Cytosol Kinesin Complex Microtubule Associated Complex Cytoplasmic Microtubule Cell Cortex 1-alkyl-2-acetylglycerophosphocholine Esterase Complex Cell Leading Edge Motile Cilium Nuclear Membrane Stereocilium Neuron Projection Neuronal Cell Body Synapse Perinuclear Region Of Cytoplasm Extracellular Exosome Central Region Of Growth Cone Axon Cytoplasm
	Molecular Function	Protein Binding Microtubule Binding Protein Kinase Binding	Protein Binding Microtubule Binding Heparin Binding Dynactin Binding Identical Protein Binding Phospholipase Binding Dynein Intermediate Chain Binding Protein Heterodimerization Activity Microtubule Plus-end Binding Phosphoprotein Binding Dynein Complex Binding
	Biological Process	Neuron Migration Nervous System Development Central Nervous System Development Axoneme Assembly Intracellular Signal Transduction Photoreceptor Cell Development Retina Development In Camera-type Eye	Establishment Of Mitotic Spindle Orientation Microtubule Cytoskeleton Organization Ameboidal-type Cell Migration Acrosome Assembly Neuron Migration Positive Regulation Of Cytokine-mediated Signaling Pathway Microtubule-based Process Nuclear Migration Chemical Synaptic Transmission Germ Cell Development Neuroblast Proliferation Learning Or Memory Retrograde Axonal Transport Adult Locomotory Behavior Protein Secretion Negative Regulation Of Neuron Projection Development Lipid Catabolic Process Stem Cell Division Transmission Of Nerve Impulse Corpus Callosum Morphogenesis Hippocampus Development Layer Formation In Cerebral Cortex Cerebral Cortex Neuron Differentiation Cerebral Cortex Development Actin Cytoskeleton Organization Microtubule Organizing Center Organization Osteoclast Development Reelin-mediated Signaling Pathway Positive Regulation Of Embryonic Development Establishment Of Planar Polarity Of Embryonic Epithelium Regulation Of GTPase Activity Cortical Microtubule Organization Positive Regulation Of Axon Extension Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of JNK Cascade Platelet Activating Factor Metabolic Process Vesicle Transport Along Microtubule Brain Morphogenesis Neuromuscular Process Controlling Balance Microtubule Sliding Nuclear Membrane Disassembly Establishment Of Centrosome Localization Maintenance Of Centrosome Location Auditory Receptor Cell Development Positive Regulation Of Dendritic Spine Morphogenesis Regulation Of Microtubule Cytoskeleton Organization Cochlea Development Microtubule Cytoskeleton Organization Involved In Establishment Of Planar Polarity
Pathways		Neurofascin interactions	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase AURKA Activation by TPX2 EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS			Adverse response to drug ( 30420678) Anxiety ( 33859377) Depression ( 33859377) Mean platelet volume ( 32888494) Neurociticism ( 29500382) Neuroticism ( 27089181) Self-reported tiredness ( 28194004)
Interacting Genes		39 interacting genes: ACD AP1M1 AP2M1 APP BICD2 CALCOCO2 CDK5 FBXO25 FSD2 GOLGA2 HOOK2 IKZF1 KIFC3 KRT40 KRTAP10-8 MAPK9 MEOX1 MEOX2 MID2 MTUS2 NFASC PAFAH1B1 POT1 PPP1CA PPP1R9B RBM5 RINT1 SPAG5 SPP1 TERF1 TINF2 TRIM23 TRIM27 TRIM39 USP9X VPS52 ZBTB10 ZBTB5 ZRANB1	23 interacting genes: CLIP1 CSNK2A1 DAB1 DCTN1 DCTN2 DCX DNAI1 DYNC1H1 FBXO7 HSPH1 KARS1 KATNA1 KATNB1 MAP1B MAP2 NDE1 NDEL1 NUDC PAFAH1B2 PAFAH1B3 PDE4D TNIK TUBA1A
Entrez ID		1641	5048
HPRD ID		02127	03329
Ensembl ID		ENSG00000077279	ENSG00000007168
Uniprot IDs		A8K340 O43602	A0A6Q8PFT2 A0A6Q8PFU3 P43034
PDB IDs		1MJD 2BQQ 2XRP 4ATU 5IKC 5IN7 5IO9 5IOI 5IP4 6FNZ 6REV 6RF2 6RF8 6RFD
Enriched GO Terms of Interacting Partners?
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