DCTN1 and TMED5

		DCTN1	TMED5
Description		dynactin subunit 1	transmembrane p24 trafficking protein 5
Image			No pdb structure
GO Annotations	Cellular Component	Kinetochore Spindle Pole Nucleus Nuclear Envelope Cytoplasm Centrosome Centriole Spindle Cytosol Microtubule Microtubule Associated Complex Cell Cortex Microtubule Cytoskeleton Membrane Dynein Complex Axon Microtubule Plus-end Neuron Projection Neuronal Cell Body Intercellular Bridge Mitotic Spindle Cell Cortex Region Centriolar Subdistal Appendage	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Cis-Golgi Network Integral Component Of Membrane COPII-coated ER To Golgi Transport Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Endoplasmic Reticulum Exit Site
	Molecular Function	Protein Binding Microtubule Binding Tubulin Binding Protein Kinase Binding Tau Protein Binding Microtubule Plus-end Binding	Protein Binding
	Biological Process	Establishment Of Mitotic Spindle Orientation Mitotic Cell Cycle Nuclear Migration Nervous System Development Neuromuscular Junction Development Centriole-centriole Cohesion Ventral Spinal Cord Development Positive Regulation Of Microtubule Polymerization Cytoplasmic Microtubule Organization Microtubule Anchoring At Centrosome Retrograde Transport, Endosome To Golgi Neuromuscular Process Nuclear Membrane Disassembly Cell Division Regulation Of Mitotic Spindle Organization Motor Behavior Neuron Cellular Homeostasis Positive Regulation Of Microtubule Nucleation Axonal Transport Maintenance Of Synapse Structure Positive Regulation Of Neuromuscular Junction Development Non-motile Cilium Assembly Neuron Projection Maintenance	Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Golgi Organization Golgi Ribbon Formation
Pathways		MHC class II antigen presentation HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand XBP1(S) activates chaperone genes COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Signaling by ALK fusions and activated point mutants	WNT ligand biogenesis and trafficking
Drugs
Diseases
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Refractive error ( 32231278)	High density lipoprotein cholesterol levels ( 29403010)
Interacting Genes		51 interacting genes: ACTR1A ACTR1B AKT1 APEX1 BBS1 BBS4 BICD1 BICD2 CASP2 CASP3 CASP7 CDC37 CLIP1 DCTN3 DISC1 DST DTNBP1 DYNC1I2 ENO3 FBXL5 FXR1 GRB2 GSK3B HAP1 HOXA1 HSPB2 KIAA0408 KIF11 KMT2A KRT5 MAP2K3 MAP2K6 MAPRE1 MED14 MTERF1 NEK2 NOD2 PAFAH1B1 PFDN1 PGAM1 PPP1CA RAB6A RBL2 RPGR SEC23A SPTBN2 STAT1 TMED5 TP53RK VIM ZNF512B	6 interacting genes: CXCL9 DCTN1 KIF21B PCSK9 PRMT6 TRMT13
Entrez ID		1639	50999
HPRD ID		07206	13028
Ensembl ID		ENSG00000204843	ENSG00000117500
Uniprot IDs		Q14203 Q6MZZ3	Q9Y3A6
PDB IDs		1TXQ 2COY 2HKN 2HKQ 2HL3 2HL5 2HQH 3E2U 3TQ7
Enriched GO Terms of Interacting Partners?
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