DAP and TRIO

		DAP	TRIO
Description		death associated protein	trio Rho guanine nucleotide exchange factor
Image		No pdb structure
GO Annotations	Cellular Component		Cytosol Cell Projection
	Molecular Function	Death Domain Binding	Protein Serine/threonine Kinase Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding ATP Binding Protein Serine Kinase Activity
	Biological Process	Autophagy Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Autophagy Negative Regulation Of NF-kappaB Transcription Factor Activity Cellular Response To Amino Acid Starvation Negative Regulation Of Transcription, DNA-templated Apoptotic Signaling Pathway	Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway Axon Guidance Central Nervous System Development Negative Regulation Of Fat Cell Differentiation Neuron Projection Morphogenesis Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction
Pathways			NRAGE signals death through JNK G alpha (q) signalling events G alpha (12/13) signalling events DCC mediated attractive signaling DCC mediated attractive signaling RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle
Drugs
Diseases
GWAS		Basophil percentage of white cells ( 32888494) Cervical high-risk human papilloma virus infection (persistent) ( 33225922) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Gut microbiota (functional units) ( 27694959) Height ( 28270201) Inflammatory bowel disease ( 28067908 23128233) Lymphocyte percentage of white cells ( 32888494) Metabolite levels ( 23823483) Metabolite levels (Pyroglutamine) ( 23934736) Pulse pressure ( 27841878) Sum eosinophil basophil counts ( 27863252) Systolic blood pressure ( 27841878) Ulcerative colitis ( 21297633)	Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel) ( 24025145) Antidepressant treatment resistance (number of drugs prescribed) ( 30700811) Asthma ( 31959851) Asthma (childhood onset) ( 31036433) Electroencephalogram traits ( 25387704) High density lipoprotein cholesterol levels ( 30498476) Intake of total sugars ( 31005972) Major depressive disorder ( 27777418) Paclitaxel-induced neuropathy ( 23776197) Physiological dysregulation (Mahalanobis distance) ( 32235003) Response to selenium supplementation (change in plasma selenium concentration) ( 33382417) Waist circumference ( 28552196)
Interacting Genes		4 interacting genes: DNAH5 RASGRP1 SETDB1 TRIO	17 interacting genes: BLMH CDC42 CDC5L DAP DISC1 DNAH5 EXOC1 FLNA ITSN2 LIMS1 MARCHF6 NIPBL PRMT7 PTK2 PTPRF RAC1 RHOA
Entrez ID		1611	7204
HPRD ID		02977	03537
Ensembl ID		ENSG00000112977	ENSG00000038382
Uniprot IDs		B4DQ75 P51397	O75962
PDB IDs			1NTY 2NZ8 6D8Z
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?