DACH1 and C1orf35

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid, two hybrid)

		DACH1	C1orf35
Description		dachshund family transcription factor 1	chromosome 1 open reading frame 35
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Transcription Regulator Complex Cytoplasm	Extracellular Region Secretory Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding	RNA Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Suckling Behavior Regulation Of Transcription By RNA Polymerase II Respiratory Gaseous Exchange By Respiratory System Cell Population Proliferation Negative Regulation Of Transcription By Competitive Promoter Binding Negative Regulation Of Cell Migration Regulation Of Nuclear Cell Cycle DNA Replication Negative Regulation Of Transcription, DNA-templated Development Of Primary Female Sexual Characteristics Negative Regulation Of Fibroblast Proliferation Negative Regulation Of Cell Proliferation Involved In Contact Inhibition Negative Regulation Of DNA Biosynthetic Process
Pathways			Neutrophil degranulation
Drugs
Diseases
GWAS		Adverse response to lamotrigine and phenytoin ( 22379998) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Blood urea nitrogen levels ( 31152163 29403010) Chronic kidney disease ( 20383146) Chronotype ( 30696823) Cleft palate ( 30452639) Creatinine levels ( 29403010) Diastolic blood pressure ( 30224653 29343252) Estimated glomerular filtration rate ( 31152163 31015462 31451708 30604766) Estimated glomerular filtration rate in non-diabetics ( 31451708) Glomerular filtration rate ( 29403010) Glomerular filtration rate (creatinine) ( 28452372 26831199) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Longevity ( 20834067) Medication use (diuretics) ( 31015401) Metabolite levels ( 23823483) Obsessive-compulsive disorder ( 22889921) Platelet count ( 32888494) Plateletcrit ( 32888494 27863252) Response to fenofibrate (HDL cholesterol levels) ( 27002377) Restless legs syndrome ( 29029846) Serum uric acid levels ( 30993211) Stroke ( 29531354) Total cholesterol levels ( 30498476) Ulna and radius bone mineral density ( 30172743) Urate levels ( 31578528 23263486) Verbal declarative memory ( 25648963) White blood cell count ( 31217584)
Interacting Genes		34 interacting genes: AHCYL1 AURKA C1orf35 CREBBP EYA1 EYA3 FGF12 FOXO1 HTR2A JUN MYC MYCBP2 NAGK NCOR1 NF2 NFIC PPIG PRKAR1B RNF14 SIN3A SIX1 SMAD1 SMAD3 SMAD4 SOX3 SOX4 SRSF11 STK11 TCF3 TEAD2 TERT U2AF2 UBE2I ZCCHC10	40 interacting genes: AP2M1 APP ARL6IP4 C4orf45 CCNL1 CEP70 CSNK2A1 CT45A1 DACH1 DVL3 FAM133A FXR1 FXR2 GAS8 GKAP1 GOLGA2 GOLGA6L9 HSF2BP INCA1 MID2 MIPOL1 MTUS2 NKAPD1 PICK1 PLEKHF2 RBMX2 RINT1 RNF151 RP9 SDCBP SDCBP2 SRPK2 SRRM4 STAC3 TERF1 THAP1 TRIM54 TRIM55 TRIM63 ZRANB1
Entrez ID		1602	79169
HPRD ID		16031	10090
Ensembl ID		ENSG00000276644	ENSG00000143793
Uniprot IDs		Q9UI36	Q9BU76
PDB IDs		1L8R
Enriched GO Terms of Interacting Partners?
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