CYP19A1 and CRBN

Number of citations of the paper that reports this interaction (PubMedID 32219443)
1

Data Source:
BioGRID (pull down)

		CYP19A1	CRBN
Description		cytochrome P450 family 19 subfamily A member 1	cereblon
Image
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane	Nucleus Cytoplasm Cytosol Membrane Cul4A-RING E3 Ubiquitin Ligase Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Iron Ion Binding Steroid Hydroxylase Activity Electron Transfer Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Oxygen Binding Heme Binding Aromatase Activity	Protein Binding Transmembrane Transporter Binding Metal Ion Binding
	Biological Process	Steroid Biosynthetic Process Estrogen Biosynthetic Process Androgen Catabolic Process Female Gonad Development Sterol Metabolic Process Electron Transport Chain Response To Estradiol Positive Regulation Of Estradiol Secretion	Protein Ubiquitination Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Protein-containing Complex Assembly Locomotory Exploration Behavior Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Large Conductance Calcium-activated Potassium Channel Activity
Pathways		Estrogen biosynthesis Endogenous sterols Defective CYP19A1 causes AEXS	Potential therapeutics for SARS
Drugs		Nicotine Aminoglutethimide Estrone Testolactone Exemestane Letrozole Anastrozole 2-Methoxyestradiol Naringenin Glyphosate MPI-674	Lenalidomide Thalidomide Pomalidomide
Diseases
GWAS		Airway wall thickness ( 25517131) Aspartate aminotransferase levels ( 33547301) Breast cancer ( 31757997) Cerebrospinal fluid AB1-42 levels ( 20932310) Endometrial cancer ( 30093612 27135401) Endometrial cancer (endometrioid histology) ( 30093612) Endometrial endometrioid carcinoma ( 27135401) Estradiol levels ( 22675492 29325096 34255042) Estrone levels ( 29325096) Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer ( 28429243) Follicle stimulating hormone levels ( 24049095) Heel bone mineral density ( 30598549 28869591) Height ( 20881960 25282103 25429064 31562340 23456168 33713608 20189936) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Hormone measurements ( 24049095) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lymphocyte percentage of white cells ( 32888494) Menarche (age at onset) ( 23599027) Neutrophil percentage of white cells ( 32888494) Response to fenofibrate (HDL cholesterol levels) ( 27002377) Reticulocyte count ( 32888494) Serum alkaline phosphatase levels ( 33547301 29403010) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Total body bone mineral density ( 29304378) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 32888494 27863252) Immune response to smallpox vaccine (IL-6) ( 22542470) Knee osteoarthritis ( 27696742) Malaria ( 31844061) Restless legs syndrome ( 29029846) White blood cell count (basophil) ( 29403010 27863252) White matter integrity ( 23218918)
Interacting Genes		2 interacting genes: CRBN FANCG	38 interacting genes: APPL2 BCL6 BCL6B BSG CSNK1A1 CUL4B CYP19A1 EGR1 EGR4 GLUL GRB2 GSPT1 GZF1 HIC1 HIC2 IKZF3 KDM1A KPNB1 MISP OSR1 OSR2 PAK5 PIK3R3 PRKAG1 RBPMS RBX1 SALL1 SALL3 SALL4 SLC16A1 SQSTM1 SUV39H1 TP53 UBE2D1 WIZ ZBTB7A ZBTB7B ZFP91
Entrez ID		1588	51185
HPRD ID		00488	16750
Ensembl ID		ENSG00000137869	ENSG00000113851
Uniprot IDs		A0A024R5S8 A8K6W3 P11511 Q05CU4 Q8IYG4 Q8TCA4	Q96SW2
PDB IDs		1TQA 3EQM 3S79 3S7S 4GL5 4GL7 4KQ8 5JKV 5JKW 5JL6 5JL7 5JL9	4M91 4TZ4 5FQD 5HXB 5V3O 6BN7 6BN8 6BN9 6BNB 6BOY 6H0F 6H0G 6UML 6XK9 7BQU 7BQV
Enriched GO Terms of Interacting Partners?
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