CTSZ and KRTAP2-3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		CTSZ	KRTAP2-3
Description		cathepsin Z	keratin associated protein 2-3
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Lysosome Endoplasmic Reticulum Endoplasmic Reticulum Lumen Plasma Membrane Cell Surface COPII-coated ER To Golgi Transport Vesicle Growth Cone Cytoplasmic Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Specific Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome Cell Cortex Region Ficolin-1-rich Granule Lumen	Cytosol Keratin Filament
	Molecular Function	Carboxypeptidase Activity Cysteine-type Endopeptidase Activity Protein Binding Cysteine-type Peptidase Activity	Protein Binding
	Biological Process	Angiotensin Maturation Proteolysis Negative Regulation Of Plasminogen Activation Negative Regulation Of Neuron Projection Development Negative Regulation Of Protein Binding Positive Regulation Of Neuron Apoptotic Process Proteolysis Involved In Cellular Protein Catabolic Process Epithelial Tube Branching Involved In Lung Morphogenesis Regulation Of Neuron Death Positive Regulation Of Neural Precursor Cell Proliferation
Pathways		Metabolism of Angiotensinogen to Angiotensins COPII-mediated vesicle transport Lysosome Vesicle Biogenesis Cargo concentration in the ER Neutrophil degranulation	Keratinization Keratinization
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Hematocrit ( 32888494) Inflammatory bowel disease ( 23128233) Lymphocyte counts ( 32888494) Mean platelet volume ( 22139419 24026423 32888494 27863252) Platelet count ( 32888494) Platelet distribution width ( 32888494 27863252)
Interacting Genes		21 interacting genes: BACH2 BANP CYSRT1 FHL5 HSF2BP KRT35 KRT40 KRTAP1-1 KRTAP10-1 KRTAP10-10 KRTAP2-3 KRTAP2-4 KRTAP3-3 KRTAP5-9 KRTAP6-3 MID2 MTUS2 NBPF19 NOTCH2NLA PLSCR1 TNS2	89 interacting genes: ADAMTSL3 BAHD1 BCL6B BEX2 C11orf87 CATSPER1 CHIC2 CREB5 CTSZ CXCL16 CYSRT1 DHX57 DMRT3 FAM161A GEMIN4 GGN HAPLN2 HHEX HOXA1 HOXB9 IGSF8 ITGB4 JOSD1 KLHL38 KRTAP1-1 KRTAP10-1 KRTAP12-4 KRTAP4-11 KRTAP4-12 KRTAP4-4 KRTAP5-11 KRTAP5-2 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE1B LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3C LCE3D LNX1 MCRS1 MOBP NBPF19 NKD1 NOTCH2NLA NPDC1 NUFIP2 OTX1 P2RY6 PHLDA1 PIGS PRKAB2 RHBDL1 SDC3 SHFL SPATA3 SPRED2 TFAP2D TNP2 TRIM42 TTPA VASN VWC2 YY1 ZBTB24 ZDHHC1 ZIM2 ZNF165 ZNF264 ZNF440 ZNF491 ZNF524 ZNF564 ZNF575 ZNF578 ZNF581 ZNF587 ZNF672 ZNF764 ZNF786 ZNF792
Entrez ID		1522	730755
HPRD ID		04410
Ensembl ID		ENSG00000101160	ENSG00000212724
Uniprot IDs		Q9UBR2	P0C7H8 Q9BYR9
PDB IDs		1DEU 1EF7
Enriched GO Terms of Interacting Partners?
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