CTBP1 and RBBP8

Number of citations of the paper that reports this interaction (PubMedID 9535825)
61

Data Source:
HPRD (in vivo, in vitro, two hybrid)

		CTBP1	RBBP8
Description		C-terminal binding protein 1	RB binding protein 8, endonuclease
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Repressor Complex Presynaptic Active Zone Cytoplasmic Component Glutamatergic Synapse GABA-ergic Synapse	Nucleus Nucleoplasm Transcription Repressor Complex Site Of Double-strand Break Intracellular Membrane-bounded Organelle
	Molecular Function	Transcription Corepressor Binding Chromatin Binding Transcription Corepressor Activity Protein Binding Protein C-terminus Binding Transcription Factor Binding Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Protein Domain Specific Binding Identical Protein Binding NAD Binding DNA-binding Transcription Factor Binding	Single-stranded DNA Endodeoxyribonuclease Activity Y-form DNA Binding Double-strand/single-strand DNA Junction Binding Damaged DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Transcription Corepressor Activity Protein Binding Identical Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Flap-structured DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Negative Regulation Of Cell Population Proliferation Viral Genome Replication Positive Regulation Of Histone Deacetylation Negative Regulation Of Histone Acetylation Negative Regulation Of Transcription, DNA-templated White Fat Cell Differentiation Regulation Of Cell Cycle Negative Regulation Of Histone H4 Acetylation	G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Homologous Recombination Blastocyst Hatching DNA Repair Regulation Of Transcription By RNA Polymerase II DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Response To Estradiol Negative Regulation Of Transcription, DNA-templated Cell Division Meiotic Cell Cycle Nucleic Acid Phosphodiester Bond Hydrolysis
Pathways		Deactivation of the beta-catenin transactivating complex SUMOylation of transcription cofactors Repression of WNT target genes Signaling by TCF7L2 mutants	HDR through Single Strand Annealing (SSA) HDR through MMEJ (alt-NHEJ) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Transcriptional Regulation by E2F6 Meiotic recombination Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
Drugs		Formic acid
Diseases
GWAS		Type 2 diabetes ( 31118516 32499647)	Eosinophil percentage of white cells ( 27863252) Estradiol levels ( 34255042) Height ( 25429064 18391951) Hip circumference adjusted for BMI ( 34021172) Intracranial aneurysm ( 20364137) Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy) ( 27418160) Late-onset myasthenia gravis ( 26562150) Lung function (FEV1) ( 30061609) Lymphocyte counts ( 32888494) Scalp hair shape ( 26926045) Tuberculosis ( 20694014) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		91 interacting genes: ACTL6B AKAP9 APC ARNT2 ATXN1L BCAS3 BCL3 BMPR2 BRCA1 CBX4 CDC23 CDKN2D CEP68 CHD3 CREBBP CRY2 CTBP2 CTNNA1 DGCR6 DMRTB1 EEF1D ELAC2 ELK3 EP300 FANCC FANCF FANCG FANCL FOXP1 FOXP2 FUNDC1 GTF2B H3-4 HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HEMGN HIC1 HOXB5 HTT IKZF1 IKZF2 KAT2B KDM1A KLF12 KLF3 LNX1 MAML2 MAPK9 MARCHF10 MECOM NME2 NOL4 NOL4L NOS1 NRIP1 NTAQ1 ORC4 PIAS2 PLCB1 PNN PRKAA1 PRKCI RAI2 RB1 RBBP5 RBBP8 RBM14 RCOR1 RNF111 SIN3A SNRPN SOBP SPEN TBP TCF4 TEAD4 TERF2 TERF2IP TGIF1 THAP11 TSHZ3 ZBP1 ZBTB18 ZEB1 ZEB2 ZFPM2 ZNF219	36 interacting genes: ATM BARD1 BRCA1 CLU CTBP1 CUL3 DNA2 FXR2 FZR1 HID1 IGFBP7 IKBKG IKZF1 IKZF3 KLHL15 LIMS1 LMO1 LMO2 LMO4 MAP2K4 NTAQ1 PAN2 PCNA PIN1 PRRG4 RAF1 RB1 RBL1 RBL2 RGS17 SIAH1 SIAH2 TGIF2 TMEM54 TOPBP1 USP4
Entrez ID		1487	5932
HPRD ID		04015	04990
Ensembl ID		ENSG00000159692	ENSG00000101773
Uniprot IDs		Q13363 X5D8Y5	A0A024RC34 Q99708
PDB IDs		1MX3 4LCE 4U6Q 4U6S 6CDF 6CDR 6V89 6V8A 7KWM	2L4Z 4D2H
Enriched GO Terms of Interacting Partners?
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