CMTM4 and APOA4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		CMTM4	APOA4
Description		CKLF like MARVEL transmembrane domain containing 4	apolipoprotein A4
Image		No pdb structure
GO Annotations	Cellular Component	Integral Component Of Membrane	Extracellular Region Extracellular Space Early Endosome Endoplasmic Reticulum Lumen Cytosol Cell Surface Very-low-density Lipoprotein Particle High-density Lipoprotein Particle Chylomicron Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle
	Molecular Function	Protein Binding	Lipid Transporter Activity Copper Ion Binding Protein Binding Phospholipid Binding Lipid Binding Cholesterol Binding Antioxidant Activity Phosphatidylcholine Binding Identical Protein Binding Protein Homodimerization Activity Phosphatidylcholine-sterol O-acyltransferase Activator Activity Cholesterol Transfer Activity
	Biological Process		Innate Immune Response In Mucosa Cholesterol Biosynthetic Process Lipid Transport Response To Lipid Hydroperoxide Leukocyte Cell-cell Adhesion Cholesterol Metabolic Process Positive Regulation Of Cholesterol Esterification Positive Regulation Of Triglyceride Catabolic Process Lipid Catabolic Process Removal Of Superoxide Radicals Regulation Of Intestinal Cholesterol Absorption Regulation Of Cholesterol Transport Cholesterol Efflux Phospholipid Efflux Chylomicron Remodeling Very-low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Remodeling Chylomicron Assembly High-density Lipoprotein Particle Assembly Negative Regulation Of Plasma Lipoprotein Oxidation Response To Stilbenoid Lipoprotein Metabolic Process Cholesterol Homeostasis Hydrogen Peroxide Catabolic Process Reverse Cholesterol Transport Positive Regulation Of Fatty Acid Biosynthetic Process Phosphatidylcholine Metabolic Process Positive Regulation Of Lipid Biosynthetic Process Positive Regulation Of Lipoprotein Lipase Activity Lipid Homeostasis Protein-lipid Complex Assembly Triglyceride Homeostasis Intermembrane Lipid Transfer
Pathways			Chylomicron assembly Assembly of active LPL and LIPC lipase complexes Chylomicron remodeling Retinoid metabolism and transport Retinoid metabolism and transport Amyloid fiber formation
Drugs			Zinc Copper Zinc acetate
Diseases
GWAS			Apolipoprotein A-IV levels ( 27412012) Body mass index ( 31978080) Cholesterol, total ( 19060911 20686565) Coronary artery disease ( 29263402) Coronary heart disease ( 21378990) Delirium ( 29631748) Fasting triglyceride levels ( 32603185) HDL cholesterol ( 20864672 19060906 20686565 26582766) HDL cholesterol levels ( 28334899) Hematological and biochemical traits ( 20139978) Hypertriglyceridemia ( 23505323) LDL cholesterol ( 20864672 19060911 20686565) LDL cholesterol levels ( 28334899) Lipid metabolism phenotypes ( 22286219) Lipid traits ( 24386095) Metabolic syndrome ( 30382898) Metabolite levels ( 22916037) Postprandial triglyceride levels ( 32603185) Total cholesterol levels ( 28334899 29403010 29615537) Triglyceride levels ( 32203549 28334899 26763881 28371326 29615537 32335043) Triglycerides ( 19074352 21909109 18193043 18193044 20864672 19060906 19060911 20139978 20686565 26582766)
Interacting Genes		20 interacting genes: APOA4 APPL1 COQ8A DAPK1 DGCR6L DIABLO HSBP1L1 MIDN MRPL2 PBX3 PTPN9 SMG9 SNX1 SPG21 SSX3 STAR TBRG4 TCEA2 TTPA ZFYVE21	6 interacting genes: AGTRAP CMTM4 CMTM5 GPLD1 HSP90AA1 MAGEA6
Entrez ID		146223	337
HPRD ID		07435	00130
Ensembl ID		ENSG00000183723	ENSG00000110244
Uniprot IDs		Q8IZR5	P06727
PDB IDs			3S84
Enriched GO Terms of Interacting Partners?
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