CSNK2A2 and ATG16L1

Number of citations of the paper that reports this interaction (PubMedID 26083323)
19

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		CSNK2A2	ATG16L1
Description		casein kinase 2 alpha 2	autophagy related 16 like 1
Image
GO Annotations	Cellular Component	Chromatin Acrosomal Vesicle Nucleus Nucleoplasm Cytosol Plasma Membrane Protein Kinase CK2 Complex	Autophagosome Membrane Autophagosome Cytosol Axoneme Phagophore Assembly Site Membrane Vacuole-isolation Membrane Contact Site
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein N-terminus Binding Protein Serine Kinase Activity	Protein Binding Ubiquitin-like Protein Transferase Activity Identical Protein Binding GTPase Binding
	Biological Process	Apoptotic Process Cell Cycle Spermatogenesis Wnt Signaling Pathway Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Cerebral Cortex Development Regulation Of Cell Cycle Liver Regeneration Regulation Of Autophagy Of Mitochondrion Positive Regulation Of Protein Targeting To Mitochondrion Regulation Of Chromosome Separation Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Apoptotic Signaling Pathway	Autophagosome Assembly Positive Regulation Of Autophagy Protein Transport Macroautophagy Protein Localization To Phagophore Assembly Site Negative Stranded Viral RNA Replication Protein Lipidation Involved In Autophagosome Assembly Xenophagy
Pathways		Synthesis of PC WNT mediated activation of DVL Condensation of Prometaphase Chromosomes Signal transduction by L1 Regulation of TP53 Activity through Phosphorylation Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding ROS sensing by NFE2L2 Receptor Mediated Mitophagy RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN stability and activity	Macroautophagy Macroautophagy
Drugs		[1-(6-{6-[(1-methylethyl)amino]-1H-indazol-1-yl}pyrazin-2-yl)-1H-pyrrol-3-yl]acetic acid Fostamatinib
Diseases
GWAS		Primary biliary cholangitis ( 28425483) Rosacea symptom severity ( 29771307) Systemic lupus erythematosus ( 28714469) Telomere length ( 24795349)	Bilirubin levels ( 31801373 31319653 32084209) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 18587394 28067908 20570966 22936669 22412388 17435756 17554300 21102463 23128233) Inflammatory bowel disease ( 28067908) Pediatric autoimmune diseases ( 26301688) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		107 interacting genes: ABCA1 ACACA ADH1A AMFR AQP4 ARRB2 ASL ATF1 ATF2 ATG16L1 BHLHE41 BID CABP1 CALM1 CASQ2 CAV1 CDC37 CLTB CREBBP CREM CSN3 CSNK2B CTDP1 DCPS DELEC1 EEF1B2 EIF2B2 EIF2B5 EIF4EBP1 ERCC6 ERH FGF1 FGF2 FKBP3 FOS GOT2 GRIN2A GRIN2B GTF2A1 GTF2A1L H1-2 HDAC1 HDAC2 HDAC6 HMGA1 HMGA2 HNRNPC HSP90AA1 HSP90B1 HSPH1 IL16 KDM1A KIF1C KLF1 LAMC3 LGALS3 MAF1 MAPK14 MDM2 MGMT MS4A1 MYC MYCN MYF5 NAP1L4 NCL NR1D2 P4HB PAK1 PICK1 PIN1 PIN4 PPP1R1B PPP1R2 PPP1R8 PRNP PTEN PTPN1 PTPRC RAD1 RAD9A RELA RGS19 SAT1 SLC18A2 SMURF1 SNCA SNX6 SPIB SPP1 STX1A TCF7L2 TCOF1 TGFBR1 TGM2 TOP1 TP53 TP63 TRIM41 TTLL12 UBE2R2 WAS XRCC1 ZNF219 ZNF423 ZNF670 ZNHIT3	18 interacting genes: APP ATG5 C3 CSNK2A1 CSNK2A2 DEDD2 GAN GIGYF2 NOD1 NOD2 OPTN PLD3 RAB33A RAB33B SCAP SETD7 TRAF3IP3 ZFP36
Entrez ID		1459	55054
HPRD ID		00279	16498
Ensembl ID		ENSG00000070770	ENSG00000085978
Uniprot IDs		H3BNI9 P19784	A0A024R494 A0A024R4B6 Q17RG0 Q53SV2 Q676U5
PDB IDs		3E3B 3OFM 3U87 5M4U 5M56 5OOI 5Y9M 5YF9 5YWM 6HMB 6HMC 6HMD 6HMQ 6L20 6QY8 6QY9 6TE2 6TEW 6TGU 7A1B 7A1Z 7A22 7A2H	4GDK 4GDL 4NAW 4TQ0 5D7G 5NPV 5NPW 5NUV 5ZYX
Enriched GO Terms of Interacting Partners?
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