SESN3 and WDR24

Number of citations of the paper that reports this interaction (PubMedID 25263562)
166

Data Source:
BioGRID (pull down)

		SESN3	WDR24
Description		sestrin 3	WD repeat domain 24
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm TORC2 Complex	Lysosomal Membrane Cytosol Intracellular Membrane-bounded Organelle GATOR2 Complex
	Molecular Function	Protein Binding Oxidoreductase Activity, Acting On Peroxide As Acceptor Leucine Binding	Protein Binding
	Biological Process	Positive Regulation Of Macroautophagy Response To Insulin Cellular Response To Amino Acid Starvation TORC2 Signaling Cellular Response To Glucose Starvation Glucose Homeostasis Regulation Of Insulin Receptor Signaling Pathway Regulation Of Protein Kinase B Signaling Cellular Response To Leucine Regulation Of Response To Reactive Oxygen Species Negative Regulation Of TORC1 Signaling Cellular Response To Leucine Starvation	Autophagy Regulation Of Autophagy Positive Regulation Of TOR Signaling Cellular Response To Amino Acid Starvation
Pathways		TP53 Regulates Metabolic Genes	Amino acids regulate mTORC1
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Aspartate aminotransferase levels ( 33547301) Chronotype ( 30696823) Common carotid intima-media thickness ( 29206233) Common carotid intima-media thickness in HIV infection ( 29206233) Diastolic blood pressure ( 27841878) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Triglyceride levels x loop diuretics use interaction ( 31806883)	Age at first sexual intercourse ( 34211149) Hip circumference adjusted for BMI ( 34021172) Smoking initiation (ever regular vs never regular) ( 30679032)
Interacting Genes		4 interacting genes: MIOS NPRL3 WDR24 WDR59	5 interacting genes: APPBP2 FBXO7 SESN1 SESN3 SRPK2
Entrez ID		143686	84219
HPRD ID		09682	15665
Ensembl ID		ENSG00000149212	ENSG00000127580
Uniprot IDs		P58005	Q96S15
PDB IDs
Enriched GO Terms of Interacting Partners?
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