GAB3 and CSF1

Number of citations of the paper that reports this interaction (PubMedID 11739737)
26

Data Source:
HPRD (in vivo)

		GAB3	CSF1
Description		GRB2 associated binding protein 3	colony stimulating factor 1
Image		No pdb structure
GO Annotations	Cellular Component		Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane Membrane Integral Component Of Membrane Nuclear Body Perinuclear Region Of Cytoplasm CSF1-CSF1R Complex
	Molecular Function		Cytokine Activity Macrophage Colony-stimulating Factor Receptor Binding Protein Binding Growth Factor Activity Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Macrophage Differentiation	Positive Regulation Of Cell-matrix Adhesion Osteoclast Proliferation Response To Ischemia Developmental Process Involved In Reproduction Inflammatory Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Macrophage Chemotaxis Macrophage Differentiation Regulation Of Ossification Osteoclast Differentiation Positive Regulation Of Cell Migration Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Mononuclear Cell Proliferation Macrophage Colony-stimulating Factor Signaling Pathway Positive Regulation Of Multicellular Organism Growth Monocyte Activation Positive Regulation Of Odontogenesis Of Dentin-containing Tooth Innate Immune Response Positive Regulation Of Macrophage Differentiation Positive Regulation Of Monocyte Differentiation Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Protein Kinase Activity Positive Regulation Of Ras Protein Signal Transduction Homeostasis Of Number Of Cells Within A Tissue Branching Involved In Mammary Gland Duct Morphogenesis Mammary Gland Fat Development Mammary Duct Terminal End Bud Growth Microglial Cell Proliferation Negative Regulation Of Neuron Death Positive Regulation Of Macrophage Colony-stimulating Factor Signaling Pathway Positive Regulation Of Microglial Cell Migration Positive Regulation Of Macrophage Migration
Pathways			Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Other interleukin signaling Interleukin-10 signaling Post-translational protein phosphorylation
Drugs
Diseases
GWAS		Glycated hemoglobin levels ( 34059833) Iron status biomarkers (transferrin saturation) ( 28334935) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 28453575) Mean spheric corpuscular volume ( 32888494)	Adult onset Still's disease ( 32149159) Aspartate aminotransferase levels ( 33547301 29403010 33339817) Blood protein levels in cardiovascular risk ( 28369058) Creatine kinase levels ( 29403010) Cryptococcosis in HIV infection ( 33269293) Height ( 31562340) High density lipoprotein cholesterol levels ( 33339817) Lactate dehydrogenase levels ( 29403010) Lymphocyte counts ( 32888494) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494) Obesity-related traits ( 23251661) Paget's disease ( 21623375 20436471) Periventricular white matter hyperintensities ( 32517579) Platelet count ( 32888494) Plateletcrit ( 32888494) Sensory disturbances after bilateral sagittal split ramus osteotomy ( 23834954) Serum total protein level ( 29403010) Total body bone mineral density ( 29304378) White blood cell count ( 32888494 27863252)
Interacting Genes		8 interacting genes: CSF1 FYN GRAP2 GRB2 LYN PIK3R1 PTPN11 SRC	13 interacting genes: CSF1R CYSRT1 FHL3 GAB3 HLA-B KRTAP1-1 KRTAP10-8 MTUS2 NOTCH2NLA SGTA SLA2 SOCS1 TNF
Entrez ID		139716	1435
HPRD ID		06571	00388
Ensembl ID		ENSG00000160219	ENSG00000184371
Uniprot IDs		Q8WWW8	A0A024R0A1 P09603
PDB IDs			1HMC 3UEZ 3UF2 4ADF 4FA8 4WRL 4WRM 5LXF
Enriched GO Terms of Interacting Partners?
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