CRH and KRTAP1-3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		CRH	KRTAP1-3
Description		corticotropin releasing hormone	keratin associated protein 1-3
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Varicosity Perikaryon Synapse	Cytosol Keratin Filament
	Molecular Function	Signaling Receptor Binding Hormone Activity Neuropeptide Hormone Activity Protein Binding Corticotropin-releasing Hormone Activity Corticotropin-releasing Hormone Receptor 1 Binding Corticotropin-releasing Hormone Receptor 2 Binding	Structural Constituent Of Skin Epidermis
	Biological Process	Positive Regulation Of Protein Phosphorylation Synaptic Transmission, Dopaminergic Negative Regulation Of Systemic Arterial Blood Pressure Inflammatory Response Signal Transduction Chemical Synaptic Transmission Female Pregnancy Parturition Learning Or Memory Steroid Metabolic Process Positive Regulation Of Cell Population Proliferation Associative Learning Hormone-mediated Apoptotic Signaling Pathway Response To Xenobiotic Stimulus Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Norepinephrine Secretion Positive Regulation Of Circadian Sleep/wake Cycle, Wakefulness Positive Regulation Of Cell Death Regulation Of Serotonin Secretion Diterpenoid Metabolic Process Hypothalamus Development Negative Regulation Of Epinephrine Secretion Negative Regulation Of Luteinizing Hormone Secretion Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Response To Immobilization Stress Negative Regulation Of Circadian Sleep/wake Cycle, REM Sleep Response To Estrogen Positive Regulation Of CAMP-mediated Signaling Response To Ethanol Response To Ether Response To Pain Ion Homeostasis Response To Corticosterone Positive Regulation Of Corticotropin Secretion Positive Regulation Of Cortisol Secretion Long-term Synaptic Potentiation Positive Regulation Of Digestive System Process Negative Regulation Of Cell Death Negative Regulation Of Glucagon Secretion Cellular Response To Cocaine Cellular Response To Dexamethasone Stimulus Positive Regulation Of Calcium Ion Import Regulation Of NMDA Receptor Activity Positive Regulation Of Corticosterone Secretion Positive Regulation Of Behavioral Fear Response	Biological_process
Pathways		Class B/2 (Secretin family receptors) G alpha (s) signalling events MECP2 regulates transcription of neuronal ligands ADORA2B mediated anti-inflammatory cytokines production	Keratinization
Drugs		Corticotropin D-Phenylalanine 2-aminoisobutyric acid
Diseases
GWAS		Adult body size ( 32376654) Coronary heart disease event reduction (statin therapy interaction) ( 22666496)
Interacting Genes		13 interacting genes: CRHR1 CRHR2 CYSRT1 KRT31 KRTAP1-3 KRTAP1-5 KRTAP10-8 KRTAP5-9 KRTAP9-3 LYN MDFI NBPF19 NOTCH2NLA	176 interacting genes: ADAM12 AGA ALDH3B1 ALPP ATG9A BCAM BHLHE40 BMP7 BTC C19orf25 C2orf68 CATSPER1 CELF5 CHIC2 CHRD CHRNG CLDN2 CMTM8 CNNM3 COA5 COL8A1 CRCT1 CREB5 CRH CRY2 CTNNBIP1 CXCL16 CYHR1 CYP21A2 CYSRT1 DHRS1 DLGAP3 DMRT3 DOCK2 ECE1 FBXW5 GLP1R GLRX3 GNE GRAP2 GSTP1 HCK HHEX HHIPL1 HOXA1 HOXB9 HOXC8 HPCAL1 HSD3B7 IGSF8 IL10 IL16 INPP5D INS ITGB4 ITGB5 JOSD1 KLHL38 KPRP KRTAP10-1 KRTAP10-11 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP12-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE1A LCE1B LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3B LCE3C LCE3D LCE3E LCE4A LCE5A LONRF1 LRFN4 MAPKBP1 MOS MTNR1A MXD3 MXI1 MYPOP NAXD NECTIN2 NECTIN3 NID2 NMU NPBWR2 NPDC1 NR1D2 NUFIP2 OLFM2 OTX1 P3H3 PDE9A PDIA5 PHETA1 PHLDA1 PIGS PLEKHN1 PRKAA2 PRKAB2 PRPF31 PSMA1 PTK7 PTPMT1 PVR R3HDM2 RAMAC RANBP3 RASD1 RPN1 RPS19BP1 SAPCD2 SDC3 SDCBP SELENOM SHFL SLC13A5 SLC22A23 SLC23A1 SLC39A7 SLC43A2 SLC7A11 SMCP SPINT1 SPRY1 STK16 SUSD6 TACSTD2 TCAF1 TFAP2D TGFB1 THAP7 TNS2 UNC119 UTP23 UXT VASN VSTM4 WNT11 XCL2 YIPF3 YY1 ZDHHC1 ZNF330 ZNF414 ZNF417 ZNF440 ZNF446 ZNF497 ZNF587 ZNF696 ZNF764 ZNF786 ZNF837
Entrez ID		1392	81850
HPRD ID		07172	12305
Ensembl ID		ENSG00000147571	ENSG00000221880
Uniprot IDs		A0A0S2Z478 P06850	Q8IUG1
PDB IDs		1GO9 1GOE 3EHT 3EHU 6P9X
Enriched GO Terms of Interacting Partners?
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