CREB1 and MTF2

Number of citations of the paper that reports this interaction (PubMedID 20211142)
361

Data Source:
BioGRID (two hybrid)

		CREB1	MTF2
Description		cAMP responsive element binding protein 1	metal response element binding transcription factor 2
Image
GO Annotations	Cellular Component	Chromatin Euchromatin Nucleus Nucleoplasm Transcription Regulator Complex Mitochondrial Matrix Axon ATF4-CREB1 Transcription Factor Complex	Nucleus Nucleoplasm Cytoplasm Focal Adhesion
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coactivator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Enzyme Binding Hsp70 Protein Binding Histone Acetyltransferase Binding CAMP Response Element Binding Identical Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Arrestin Family Protein Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Corepressor Binding DNA Binding Chromatin Binding Methylated Histone Binding Metal Ion Binding
	Biological Process	Response To Hypoxia Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Protein Phosphorylation Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Axonogenesis Aging Lactation Memory Circadian Rhythm Regulation Of Cell Size Visual Learning Response To Xenobiotic Stimulus Response To Organic Substance Negative Regulation Of Gene Expression Negative Regulation Of Transcription By Competitive Promoter Binding Response To Activity Pituitary Gland Development Positive Regulation Of Transforming Growth Factor Beta3 Production Secretory Granule Organization Response To Glucagon Chemotaxis To Arachidonic Acid Response To Nicotine Cellular Response To Hepatocyte Growth Factor Stimulus Cellular Response To Platelet-derived Growth Factor Stimulus Positive Regulation Of Multicellular Organism Growth Regulation Of Circadian Rhythm Positive Regulation Of Apoptotic Process Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Hormone Secretion Positive Regulation Of Lipid Biosynthetic Process Regulation Of Fibroblast Proliferation Protein Stabilization Positive Regulation Of Cardiac Muscle Tissue Development Regulation Of Glial Cell Proliferation Lung Saccule Development Type I Pneumocyte Differentiation Cellular Response To Zinc Ion Cellular Response To Retinoic Acid Cellular Response To Fatty Acid Positive Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Neuron Death Response To L-glutamate Cellular Response To Nerve Growth Factor Stimulus Cellular Response To Insulin-like Growth Factor Stimulus Cellular Response To Leukemia Inhibitory Factor	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Regulation Of Transcription, DNA-templated Segment Specification Stem Cell Population Maintenance Positive Regulation Of Transcription By RNA Polymerase II Stem Cell Differentiation Negative Regulation Of Histone H3-K27 Methylation Positive Regulation Of Histone H3-K27 Methylation Cellular Response To Leukemia Inhibitory Factor
Pathways		PKA-mediated phosphorylation of CREB CaMK IV-mediated phosphorylation of CREB AKT phosphorylates targets in the nucleus CREB phosphorylation Transcriptional activation of mitochondrial biogenesis NOTCH2 intracellular domain regulates transcription NCAM signaling for neurite out-growth Circadian Clock CREB1 phosphorylation through the activation of Adenylate Cyclase CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling Constitutive Signaling by AKT1 E17K in Cancer Gastrin-CREB signalling pathway via PKC and MAPK Regulation of MECP2 expression and activity MECP2 regulates neuronal receptors and channels MECP2 regulates transcription of neuronal ligands MECP2 regulates transcription factors NGF-stimulated transcription NGF-stimulated transcription HCMV Early Events Transcriptional regulation of granulopoiesis Estrogen-dependent nuclear events downstream of ESR-membrane signaling Estrogen-dependent nuclear events downstream of ESR-membrane signaling ADORA2B mediated anti-inflammatory cytokines production ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis FCGR3A-mediated IL10 synthesis Heme signaling	PRC2 methylates histones and DNA
Drugs		Adenosine phosphate Naloxone
Diseases
GWAS		Body mass index ( 28892062 25673413) Diastolic blood pressure ( 27841878) Food antigen IgG levels ( 24962563) Mean corpuscular hemoglobin ( 32888494) Refractive error ( 32231278) Systolic blood pressure ( 27841878)	Bitter alcoholic beverage consumption ( 31046077) Chronotype ( 30696823) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Plasma clusterin levels ( 26545630) Response to lurasidone in schizophrenia ( 29730043) Triglyceride levels ( 32154731)
Interacting Genes		82 interacting genes: ABL1 AGR2 AKT1 ATF1 ATF6 ATF7IP ATM ATR CAMK2A CCDC6 CD274 CEBPB CHD3 CHD8 CREBBP CREM CRTC1 CRTC2 DNMT3L DYRK1A EDF1 ERG28 FHL5 GLI2 GSK3A GSK3B GTF2A1 GTF2F2 HIPK3 HIVEP1 HNF1B HPS6 KAT5 KCNIP3 KIAA2026 MAPK14 MAPKAPK2 MTF2 NR3C1 PDX1 PIAS1 PIAS2 POGZ POU2F1 PPP1CA PRKACA PRKG1 PTEN RAB1A RBBP4 RECQL5 RFX3 RGS13 RNF111 RNF4 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA4 RPS6KA5 SGK1 SMARCA4 SMARCA5 SMCO1 SOX9 SRA1 SREBF2 SRF SUZ12 THRA TOX4 TRIM22 TSSK4 UBE2I VIM YY1 ZHX1 ZMYM2 ZNF35 ZNF436 ZNF451 ZNF92	12 interacting genes: CDKN2D CREB1 GPRASP1 GSK3B KDM1A PIK3R3 PRKD2 PRMT6 SMAD3 SUV39H1 SUV39H2 TMED9
Entrez ID		1385	22823
HPRD ID		00442	14342
Ensembl ID		ENSG00000118260	ENSG00000143033
Uniprot IDs		B7Z5C6 P16220 Q53X93 Q5U0J5	B4DZ69 B4DZG1 Q7Z534 Q9Y483
PDB IDs		2LXT 5ZK1 5ZKO	5XFR
Enriched GO Terms of Interacting Partners?
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