CR2 and IFNA1

Number of citations of the paper that reports this interaction (PubMedID 1849076)
20

Data Source:
HPRD (in vivo)

		CR2	IFNA1
Description		complement C3d receptor 2	interferon alpha 1
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GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Integral Component Of Membrane Receptor Complex Extracellular Exosome	Extracellular Region Extracellular Space
	Molecular Function	Virus Receptor Activity Complement Binding DNA Binding Complement Receptor Activity Transmembrane Signaling Receptor Activity Protein Binding Protein Homodimerization Activity	Cytokine Activity Type I Interferon Receptor Binding Protein Binding
	Biological Process	Complement Receptor Mediated Signaling Pathway Immune Response Complement Activation, Alternative Pathway Complement Activation, Classical Pathway B Cell Differentiation B Cell Proliferation Negative Regulation Of Complement Activation, Classical Pathway Viral Entry Into Host Cell	Adaptive Immune Response T Cell Activation Involved In Immune Response Natural Killer Cell Activation Involved In Immune Response Humoral Immune Response Cytokine-mediated Signaling Pathway B Cell Differentiation Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein B Cell Proliferation Response To Exogenous DsRNA Defense Response To Virus
Pathways		Regulation of Complement cascade	Interferon alpha/beta signaling Regulation of IFNA signaling Regulation of IFNA signaling TRAF6 mediated IRF7 activation Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Alzheimer's disease or fasting insulin levels (pleiotropy) ( 30805717) Refractive error ( 32231278) Systemic sclerosis ( 29293537) Type 2 diabetes ( 21490949)
Interacting Genes		10 interacting genes: ANXA6 C3 CD19 CR1 FCER2 FHOD1 HNRNPU IFITM1 IFNA1 TP53	5 interacting genes: CR2 GLDC IFNAR1 IL2 IRF9
Entrez ID		1380	3439
HPRD ID		00399	00974
Ensembl ID		ENSG00000117322	ENSG00000197919
Uniprot IDs		P20023	L0N195 P01562
PDB IDs		1GHQ 1LY2 1W2R 1W2S 2ATY 2GSX 3OED	3UX9
Enriched GO Terms of Interacting Partners?
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