ADORA1 and TSHR

Number of citations of the paper that reports this interaction (PubMedID 28298427)
23

Data Source:
BioGRID (two hybrid)

		ADORA1	TSHR
Description		adenosine A1 receptor	thyroid stimulating hormone receptor
Image
GO Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Postsynaptic Density Basolateral Plasma Membrane Axolemma Neuronal Cell Body Terminal Bouton Dendritic Spine Calyx Of Held Presynaptic Active Zone Integral Component Of Postsynaptic Membrane Integral Component Of Presynaptic Membrane	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Basolateral Plasma Membrane Receptor Complex
	Molecular Function	G Protein-coupled Adenosine Receptor Activity G Protein-coupled Receptor Binding Purine Nucleoside Binding Protein Binding Heat Shock Protein Binding G-protein Beta/gamma-subunit Complex Binding Heterotrimeric G-protein Binding Protein Heterodimerization Activity Neurotransmitter Receptor Activity Involved In Regulation Of Presynaptic Cytosolic Calcium Ion Concentration	Thyroid-stimulating Hormone Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Signaling Receptor Activity Protein-containing Complex Binding
	Biological Process	Temperature Homeostasis Response To Hypoxia G Protein-coupled Adenosine Receptor Signaling Pathway Regulation Of Respiratory Gaseous Exchange By Nervous System Process Negative Regulation Of Acute Inflammatory Response Negative Regulation Of Leukocyte Migration Positive Regulation Of Peptide Secretion Positive Regulation Of Systemic Arterial Blood Pressure Negative Regulation Of Systemic Arterial Blood Pressure Regulation Of Glomerular Filtration Protein Targeting To Membrane Phagocytosis Inflammatory Response Signal Transduction Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Nervous System Development Negative Regulation Of Cell Population Proliferation Negative Regulation Of Glutamate Secretion Lipid Catabolic Process Negative Regulation Of Synaptic Transmission, GABAergic Positive Regulation Of Nucleoside Transport Negative Regulation Of Neurotrophin Production Positive Regulation Of Protein Dephosphorylation Negative Regulation Of Renal Sodium Excretion Negative Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Negative Regulation Of Apoptotic Process Positive Regulation Of Potassium Ion Transport Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Heart Contraction Negative Regulation Of Hormone Secretion Cognition Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Negative Regulation Of Lipid Catabolic Process Positive Regulation Of Lipid Catabolic Process Regulation Of Sensory Perception Of Pain Negative Regulation Of Synaptic Transmission, Glutamatergic Fatty Acid Homeostasis Excitatory Postsynaptic Potential Relaxation Of Vascular Associated Smooth Muscle Negative Regulation Of Mucus Secretion Triglyceride Homeostasis Regulation Of Cardiac Muscle Cell Contraction Apoptotic Signaling Pathway Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Negative Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Long-term Synaptic Depression Positive Regulation Of Neuron Death	Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Hormone-mediated Signaling Pathway Thyroid-stimulating Hormone Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis Cellular Response To Glycoprotein Cellular Response To Thyrotropin-releasing Hormone
Pathways		Adenosine P1 receptors G alpha (i) signalling events	Hormone ligand-binding receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production
Drugs		Tramadol Caffeine Theophylline Lamotrigine Adenosine Dyphylline Pentoxifylline Enprofylline Gabapentin Aminophylline Oxtriphylline Theobromine Defibrotide Tecadenoson Naxifylline Cannabidiol Istradefylline Tonapofylline Rolofylline	Thyrotropin alfa
Diseases
GWAS		Asthma ( 31361310 31959851 30929738 27182965 32296059 31619474) Asthma (childhood onset) ( 31036433 30929738) Clozapine-induced agranulocytosis ( 25187353) Systolic blood pressure ( 30224653) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Graves' disease ( 21841780 22922229) Hair morphology ( 19896111) Male sexual orientation ( 29217827) Maximal oxygen uptake response ( 25729143) Obstetric antiphospholipid syndrome ( 28424481) Optic nerve measurement (rim area) ( 20395239) Smooth-surface caries ( 24556642) Thyroid stimulating hormone levels ( 30367059 32769997) Tourette syndrome ( 30818990) Uric acid levels ( 21294900) Urinary albumin excretion ( 32277301) Visceral fat ( 22589738)
Interacting Genes		13 interacting genes: ADA ATXN1L DRD1 EPB41L2 GNAI2 GNAO1 GNAS GNAZ GRM1 NEK2 P2RY1 SNF8 TSHR	38 interacting genes: ACTB ADORA1 ADRB2 ASPHD1 BNIP1 CALR CANX CD81 CRADD FLNB FN1 GNA11 GNA12 GNA13 GNAI1 GNAI2 GNAI3 GNAO1 GNAQ GNAS HNRNPA1 HSPA5 JAK1 JAK2 JPH3 LHCGR MID1IP1 MOG PIK3R1 PTDSS1 RABAC1 RUNDC3A SCRIB STAT3 SYT1 TMCO3 TMEM119 TSHB
Entrez ID		134	7253
HPRD ID		00042	04537
Ensembl ID		ENSG00000163485	ENSG00000165409
Uniprot IDs		B7Z1L9 P30542	A0A0A0MTJ0 P16473
PDB IDs		5N2S 5UEN 6D9H	1XUM 2XWT 3G04
Enriched GO Terms of Interacting Partners?
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