UBR3 and UBE2B

Number of citations of the paper that reports this interaction (PubMedID 19549727)
74

Data Source:
BioGRID (affinity chromatography technology, two hybrid, affinity chromatography technology)

		UBR3	UBE2B
Description		ubiquitin protein ligase E3 component n-recognin 3	ubiquitin conjugating enzyme E2 B
Image		No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Cytoplasm Integral Component Of Membrane	Chromatin XY Body Nucleus Nucleoplasm Replication Fork Cytoplasm Plasma Membrane HULC Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Zinc Ion Binding Ubiquitin Protein Ligase Activity	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ubiquitin Protein Ligase Binding Ubiquitin Conjugating Enzyme Activity
	Biological Process	Suckling Behavior Ubiquitin-dependent Protein Catabolic Process Sensory Perception Of Smell Embryo Development Ending In Birth Or Egg Hatching Protein Ubiquitination Ubiquitin-dependent Protein Catabolic Process Via The N-end Rule Pathway	Protein Polyubiquitination In Utero Embryonic Development DNA Repair Postreplication Repair Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Cellular Response To DNA Damage Stimulus Spermatogenesis Sperm Axoneme Assembly Response To Xenobiotic Stimulus Response To UV Positive Regulation Of Reciprocal Meiotic Recombination Protein Ubiquitination Histone Ubiquitination Negative Regulation Of Histone Phosphorylation Histone H2A Ubiquitination Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of CAMP-mediated Signaling Meiotic Telomere Clustering Protein Stabilization Chiasma Assembly Protein Autoubiquitination Histone Lysine Demethylation Synaptonemal Complex Organization Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways			Recognition of DNA damage by PCNA-containing replication complex Synthesis of active ubiquitin: roles of E1 and E2 enzymes E3 ubiquitin ligases ubiquitinate target proteins Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Longitudinal change in brain amyloid plaque burden ( 26268530) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814) Urate levels in obese individuals ( 25811787)	Relative amplitude of rest-activity cycles ( 30120083)
Interacting Genes		8 interacting genes: APEX1 BBS5 DZIP3 MAGEC2 UBE2A UBE2B UBE2D2 UBE2H	26 interacting genes: BIRC2 CBX5 CDKN1B CNOT4 CRMP1 CTNNB1 FBN2 H2AC20 HERPUD2 MED31 PCNA PRKN RAD18 RC3H1 RC3H2 RNF20 RNF4 RNF40 TRIM14 TRIM45 UBA1 UBR1 UBR2 UBR3 UBR5 UNC119
Entrez ID		130507	7320
HPRD ID		15887	01533
Ensembl ID		ENSG00000144357	ENSG00000119048
Uniprot IDs		Q6ZT12	P63146
PDB IDs			1JAS 1NXA 2Y4W 2YB6 2YBF
Enriched GO Terms of Interacting Partners?
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