OSR1 and CRBN

Number of citations of the paper that reports this interaction (PubMedID 30385546)
64

Data Source:
BioGRID (pull down)

		OSR1	CRBN
Description		odd-skipped related transcription factor 1	cereblon
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Cytosol Extrinsic Component Of Membrane	Nucleus Cytoplasm Cytosol Membrane Cul4A-RING E3 Ubiquitin Ligase Complex Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Protein Binding Transmembrane Transporter Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Urogenital System Development Ureteric Bud Development Mesonephros Development Chondrocyte Differentiation Regulation Of Transcription By RNA Polymerase II Heart Development Gonad Development Embryo Development Positive Regulation Of Gene Expression Cell Differentiation Positive Regulation Of Bone Mineralization Negative Regulation Of Epithelial Cell Differentiation Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Embryonic Skeletal Limb Joint Morphogenesis Middle Ear Morphogenesis Odontogenesis Embryonic Digit Morphogenesis Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Intermediate Mesoderm Development Pronephros Development Stem Cell Differentiation Positive Regulation Of Epithelial Cell Proliferation Roof Of Mouth Development Embryonic Skeletal Joint Morphogenesis Cellular Response To Retinoic Acid Metanephric Mesenchyme Development Cell Proliferation Involved In Kidney Development Metanephric Mesenchyme Morphogenesis Mesangial Cell Development Metanephric Mesenchymal Cell Differentiation Posterior Mesonephric Tubule Development Specification Of Anterior Mesonephric Tubule Identity Specification Of Posterior Mesonephric Tubule Identity Mesonephric Duct Morphogenesis Negative Regulation Of Nephron Tubule Epithelial Cell Differentiation Renal Vesicle Progenitor Cell Differentiation Ureter Urothelium Development Metanephric Epithelium Development Metanephric Smooth Muscle Tissue Development Metanephric Nephron Tubule Development Metanephric Glomerulus Vasculature Development Metanephric Interstitial Fibroblast Development Pattern Specification Involved In Metanephros Development Embryonic Skeletal Joint Development Metanephric Cap Mesenchymal Cell Proliferation Involved In Metanephros Development Negative Regulation Of Creatine Transmembrane Transporter Activity Positive Regulation Of Gastrulation Negative Regulation Of Sodium Ion Transmembrane Transporter Activity	Protein Ubiquitination Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Protein-containing Complex Assembly Locomotory Exploration Behavior Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Large Conductance Calcium-activated Potassium Channel Activity
Pathways			Potential therapeutics for SARS
Drugs			Lenalidomide Thalidomide Pomalidomide
Diseases
GWAS		Childhood ear infection ( 27182965 28928442) Coronary artery disease ( 32469254 30104761 33020668) Facial morphology ( 29921221) Monobrow ( 27182965) Pulse pressure ( 26390057 27841878 28739976) Systolic blood pressure ( 27841878)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 32888494 27863252) Immune response to smallpox vaccine (IL-6) ( 22542470) Knee osteoarthritis ( 27696742) Malaria ( 31844061) Restless legs syndrome ( 29029846) White blood cell count (basophil) ( 29403010 27863252) White matter integrity ( 23218918)
Interacting Genes		3 interacting genes: CRBN TGFBR1 TGFBR2	38 interacting genes: APPL2 BCL6 BCL6B BSG CSNK1A1 CUL4B CYP19A1 EGR1 EGR4 GLUL GRB2 GSPT1 GZF1 HIC1 HIC2 IKZF3 KDM1A KPNB1 MISP OSR1 OSR2 PAK5 PIK3R3 PRKAG1 RBPMS RBX1 SALL1 SALL3 SALL4 SLC16A1 SQSTM1 SUV39H1 TP53 UBE2D1 WIZ ZBTB7A ZBTB7B ZFP91
Entrez ID		130497	51185
HPRD ID		16401	16750
Ensembl ID		ENSG00000143867	ENSG00000113851
Uniprot IDs		Q8TAX0	Q96SW2
PDB IDs			4M91 4TZ4 5FQD 5HXB 5V3O 6BN7 6BN8 6BN9 6BNB 6BOY 6H0F 6H0G 6UML 6XK9 7BQU 7BQV
Enriched GO Terms of Interacting Partners?
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