ACVR1C and TDGF1

Number of citations of the paper that reports this interaction (PubMedID 11485994)
85

Data Source:
HPRD (in vivo)

		ACVR1C	TDGF1
Description		activin A receptor type 1C	teratocarcinoma-derived growth factor 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Receptor Complex Activin Receptor Complex	Extracellular Region Extracellular Space Plasma Membrane Cell Surface Apical Plasma Membrane Extrinsic Component Of Plasma Membrane Anchored Component Of Membrane Membrane Raft
	Molecular Function	Protein Serine/threonine Kinase Activity ATP Binding Activin Receptor Activity, Type I Growth Factor Binding Nodal Binding Metal Ion Binding	Signaling Receptor Binding Protein Binding Growth Factor Activity Nodal Binding Activin Receptor Binding
	Biological Process	Trophectodermal Cell Proliferation Response To Dietary Excess Protein Phosphorylation Nervous System Development Response To Glucose Lipid Storage Cell Differentiation Apoptotic Nuclear Changes Response To Insulin Activin Receptor Signaling Pathway Nodal Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Insulin Secretion Cellular Response To Growth Factor Stimulus Negative Regulation Of Trophoblast Cell Migration Negative Regulation Of Chorionic Trophoblast Cell Proliferation	Blood Vessel Development Morphogenesis Of A Branching Structure Cell Migration Involved In Sprouting Angiogenesis Epidermal Growth Factor Receptor Signaling Pathway Determination Of Left/right Symmetry Heart Development Positive Regulation Of Cell Population Proliferation Anterior/posterior Axis Specification, Embryo Embryo Development Ending In Birth Or Egg Hatching Anterior/posterior Pattern Specification Regulation Of Signal Transduction Positive Regulation Of Endothelial Cell Migration Peptidyl-serine Phosphorylation Cell Differentiation Positive Regulation Of Cell Migration Mammary Gland Development Cellular Response To Hepatocyte Growth Factor Stimulus Nodal Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Cellular Response To Fibroblast Growth Factor Stimulus Anatomical Structure Development Positive Regulation Of Peptidyl-tyrosine Phosphorylation Cellular Response To Interferon-gamma Cellular Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor Cellular Response To Epidermal Growth Factor Stimulus
Pathways		Signaling by NODAL Regulation of signaling by NODAL Signaling by Activin Signaling by Activin	Signaling by NODAL Regulation of signaling by NODAL POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
Drugs
Diseases
GWAS		Apolipoprotein B levels ( 32203549) Birth weight ( 31043758) Body shape index ( 34021172) Diastolic blood pressure ( 30224653) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 34021172) Liver enzyme levels (alkaline phosphatase) ( 33972514) Low density lipoprotein cholesterol levels ( 32154731 33339817) Offspring birth weight ( 31043758) Reticulocyte count ( 32888494) Serum alkaline phosphatase levels ( 33547301) Systolic blood pressure ( 30578418) Total cholesterol levels ( 33339817 30275531) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)	Blood protein levels ( 29875488 28240269) Metabolite levels ( 23823483) Refractive error ( 32231278)
Interacting Genes		2 interacting genes: INHBB TDGF1	22 interacting genes: ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ANG AP2S1 BAG6 BMP4 BMP6 BMP7 BMPR1A BMPR2 COPS6 FARSA FBLN1 GDF3 GDF9 INHBB LRIF1 NODAL TGFBR2
Entrez ID		130399	6997
HPRD ID		10608	01757
Ensembl ID		ENSG00000123612	ENSG00000241186
Uniprot IDs		Q8NER5	F5H1T8 P13385
PDB IDs
Enriched GO Terms of Interacting Partners?
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