COL3A1 and AP2B1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		COL3A1	AP2B1
Description		collagen type III alpha 1 chain	adaptor related protein complex 2 subunit beta 1
Image
GO Annotations	Cellular Component	Extracellular Region Collagen Type III Trimer Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Collagen-containing Extracellular Matrix	Cytosol Plasma Membrane Membrane AP-2 Adaptor Complex Clathrin Adaptor Complex Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Endolysosome Membrane Clathrin-coated Endocytic Vesicle Postsynapse Glutamatergic Synapse
	Molecular Function	Protease Binding Integrin Binding Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength Metal Ion Binding Platelet-derived Growth Factor Binding	Signal Sequence Binding Protein Binding Clathrin Binding Clathrin Adaptor Activity Protein-containing Complex Binding
	Biological Process	Skeletal System Development Cell-matrix Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Heart Development Response To Radiation Response To Mechanical Stimulus Peptide Cross-linking Cerebral Cortex Development Platelet Activation Extracellular Matrix Organization Collagen Fibril Organization Response To Cytokine Positive Regulation Of Rho Protein Signal Transduction Wound Healing Skin Development Negative Regulation Of Immune Response Supramolecular Fiber Organization Negative Regulation Of Neuron Migration	Kidney Development Ventricular Septum Development Intracellular Protein Transport Vesicle-mediated Transport Aorta Development Positive Regulation Of Endocytosis Clathrin Coat Assembly Coronary Vasculature Development Clathrin-dependent Endocytosis Postsynaptic Neurotransmitter Receptor Internalization Negative Regulation Of Neuron Death Positive Regulation Of Protein Localization To Membrane
Pathways		Collagen degradation Collagen degradation Extracellular matrix organization Collagen biosynthesis and modifying enzymes Signaling by PDGF Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Syndecan interactions Non-integrin membrane-ECM interactions ECM proteoglycans ECM proteoglycans Scavenging by Class A Receptors NCAM1 interactions MET activates PTK2 signaling Collagen chain trimerization	Nef Mediated CD4 Down-regulation Retrograde neurotrophin signalling Retrograde neurotrophin signalling Nef Mediated CD8 Down-regulation MHC class II antigen presentation EPH-ephrin mediated repulsion of cells Recycling pathway of L1 Recycling pathway of L1 WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDLR internalisation and degradation LDL clearance Potential therapeutics for SARS
Drugs		Collagenase clostridium histolyticum
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Carotid intima media thickness x smoking interaction ( 32117412) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Parkinson disease and lewy body pathology ( 25663231) Platelet distribution width ( 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Chronotype ( 30696823) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494) Mean platelet volume ( 22139419 32888494 27863252) Mean reticulocyte volume ( 32888494) Platelet count ( 22139419 27863252) Platelet distribution width ( 27863252) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252)
Interacting Genes		15 interacting genes: AP2B1 CAPN1 DDR1 DDR2 FGF7 HTRA1 LRP2 MAG MYOC PCOLCE PDGFA PDGFB SPARC THBS1 VWF	64 interacting genes: - ACVR1 AFF4 AP1M1 AP1M2 AP2A2 AP2M1 AP2S1 APC ARRB1 ATM ATP23 ATP6V1G1 BUB1 BUB1B C2CD6 CCDC187 CLINT1 COL3A1 DHX58 DNAJC5 EFTUD2 EGFR FMNL2 GPANK1 GTF2I HIP1 HSPB1 ITSN1 KANK2 KIAA0408 KPNA2 LDLRAP1 LONRF1 LRRFIP1 MEA1 MLH1 NECAP2 NEU4 NOS2 NUP54 PIP5K1C PKP1 POM121 PSORS1C2 RAPGEF3 RIBC2 SERTAD2 SLC25A6 SLC2A8 SMAD4 SMURF1 SNAP91 TENT5C TERF2IP TEX12 TGFBR1 TGFBR2 THAP1 TUBGCP4 TXN2 U2AF1 UBC VSIG4
Entrez ID		1281	163
HPRD ID		00365	03015
Ensembl ID		ENSG00000168542	ENSG00000006125
Uniprot IDs		P02461	A0A140VJE8 P63010 Q96EL6
PDB IDs		2V53 3DMW 4AE2 4AEJ 4AK3 4GYX 6FZV 6FZW	1E42 2G30 2IV8 2IV9 2JKR 2JKT 2VGL 2XA7 4UQI 5M5R 6QH5 6QH6 6QH7 6URI 6YAE 6YAF 6YAH 6YAI
Enriched GO Terms of Interacting Partners?
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