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LRRC25 and OPRM1
Number of citations of the paper that reports this interaction (PubMedID
32296183
)
86
Data Source:
BioGRID
(two hybrid)
LRRC25
OPRM1
Description
leucine rich repeat containing 25
opioid receptor mu 1
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Cytoplasm
Integral Component Of Membrane
Endosome
Endoplasmic Reticulum
Golgi Apparatus
Plasma Membrane
Integral Component Of Plasma Membrane
Focal Adhesion
Axon
Dendrite
Dendrite Membrane
Dendrite Cytoplasm
Sarcolemma
Neuron Projection
Perikaryon
Membrane Raft
Spine Apparatus
Integral Component Of Postsynaptic Membrane
Integral Component Of Presynaptic Membrane
Molecular Function
Protein Binding
G-protein Alpha-subunit Binding
G Protein-coupled Receptor Activity
Beta-endorphin Receptor Activity
Voltage-gated Calcium Channel Activity
Protein Binding
Protein C-terminus Binding
Protein Domain Specific Binding
Filamin Binding
G-protein Beta-subunit Binding
Morphine Receptor Activity
Peptide Binding
Neuropeptide Binding
Biological Process
Acute Inflammatory Response To Antigenic Stimulus
G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway
Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway
Neuropeptide Signaling Pathway
Sensory Perception
Negative Regulation Of Cell Population Proliferation
Response To Radiation
Sensory Perception Of Pain
Adenylate Cyclase-inhibiting Opioid Receptor Signaling Pathway
Response To Food
Positive Regulation Of Appetite
Response To Lipopolysaccharide
G Protein-coupled Opioid Receptor Signaling Pathway
Wound Healing
Response To Cocaine
Eating Behavior
Estrous Cycle
Behavioral Response To Ethanol
Positive Regulation Of Neurogenesis
Regulation Of Sensory Perception Of Pain
Excitatory Postsynaptic Potential
Negative Regulation Of Wnt Protein Secretion
Positive Regulation Of ERK1 And ERK2 Cascade
Calcium Ion Transmembrane Transport
Response To Growth Factor
Cellular Response To Morphine
Regulation Of Cellular Response To Stress
Negative Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway
Regulation Of NMDA Receptor Activity
Pathways
Opioid Signalling
G-protein activation
Peptide ligand-binding receptors
G alpha (i) signalling events
Interleukin-4 and Interleukin-13 signaling
MECP2 regulates neuronal receptors and channels
Drugs
Tramadol
Morphine
Codeine
Amitriptyline
Hydromorphone
Methadone
Meperidine
Oxycodone
Levallorphan
Dextromethorphan
Butorphanol
Dextropropoxyphene
Pentazocine
Naltrexone
Sufentanil
Alfentanil
Fentanyl
Loperamide
Nalbuphine
Levorphanol
Remifentanil
Ondansetron
Anileridine
Buprenorphine
Hydrocodone
Diphenoxylate
Naloxone
Oxymorphone
Dezocine
Ketamine
Levacetylmethadol
Aripiprazole
Methadyl acetate
3-Methylthiofentanyl
Dimethylthiambutene
Diamorphine
Ethylmorphine
Etorphine
Carfentanil
Diprenorphine
Dihydromorphine
3-Methylfentanyl
V1003
Epicept NP-1
LI-301
Tapentadol
Nalmefene
Alvimopan
Morphine glucuronide
Ketobemidone
Methylnaltrexone
Naloxegol
Cannabidiol
Trimebutine
Butyrfentanyl
Pholcodine
Eluxadoline
Tianeptine
Opium
Pentoxyverine
Naldemedine
Metenkefalin
Medical Cannabis
Nabiximols
Loxicodegol
Oliceridine
Diseases
GWAS
Body size at age 10 (
32376654
)
Hyperemesis gravidarum (
29563502
)
Monocyte percentage of white cells (
32888494
27863252
)
Severity of nausea and vomiting of pregnancy (
29563502
)
Systemic lupus erythematosus (
33536424
28714469
)
White blood cell count (
32888494
)
Adult body size (
32376654
)
Body size at age 10 (
32376654
)
Diastolic blood pressure (
30224653
)
HDL cholesterol levels (
32203549
)
Hypertension (
21347282
)
Lipoprotein (a) levels (
26377243
)
Menstruation quality of life impact (fever) (
29855537
)
Methadone dose in opioid dependence (
28115739
)
Nontraumatic osteonecrosis of the femoral head (
32701715
)
Opioid use disorder (
32492095
)
Type 2 diabetes (age of onset) (
28060188
)
Interacting Genes
38 interacting genes:
ACD
AGPAT4
ANKRD46
APOL3
ATP6V0C
BMP10
BRICD5
C3orf52
CD72
CLDN19
CLEC1A
CLN6
CLRN2
CNIH3
CXCL9
DEFB121
DNAJC30
EDDM3B
FAM3C
FATE1
FPR2
GPRC5D
LHFPL5
MAL
OPRM1
PKMYT1
PNLIPRP1
SEC22A
SEC61G
SMCO4
SPNS3
TMEM120A
TMEM201
TNF
TRAF3IP3
TSPAN4
VAMP5
YIPF6
78 interacting genes:
ADAM33
ADD3
ALOX5AP
ATP6V0C
ATP6V0E1
C2CD2L
CALM1
CCDC167
CD302
CLCN7
CLDN10
CLDN22
CLDN8
CLEC12B
CLEC7A
CNIH1
COPS5
CPLX1
CTXN3
CYB561
DNAJB4
DOK4
DOK5
DRD2
EHHADH
EMP1
EMP3
FLNA
GJA4
GNA15
GNAI1
GNAI2
GNAO1
GPRASP1
GRK3
GRM1
HS6ST1
IFITM3
KCNF1
LAT
LPAR3
LRRC25
MAL
MALL
MAP1LC3A
MAP1LC3C
MFF
NELFA
NSG1
OPRD1
OPRL1
PLD2
PLD3
PMP22
PPL
RPRM
RTP4
SCGB1D1
SEC22A
SERP2
SIAH1
SIAH2
SLC30A2
SLC38A7
SLC39A13
SLC41A1
SLC9A9
SMAGP
TEX264
TM4SF4
TMBIM6
TMEM236
TRARG1
UBC
VAPA
WLS
YIPF3
ZYX
Entrez ID
126364
4988
HPRD ID
09597
02484
Ensembl ID
ENSG00000175489
ENSG00000112038
Uniprot IDs
Q8N386
B8K2Q5
G8XRH4
G8XRH5
L0E130
P35372
PDB IDs
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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