MOB3A and TGIF1

Number of citations of the paper that reports this interaction (PubMedID 21516116)
114

Data Source:
BioGRID (two hybrid)

		MOB3A	TGIF1
Description		MOB kinase activator 3A	TGFB induced factor homeobox 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Chromatin Nucleoplasm
	Molecular Function	Protein Kinase Activator Activity Metal Ion Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Co-SMAD Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Signal Transduction	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Response To Xenobiotic Stimulus Negative Regulation Of Gene Expression Cellular Response To Growth Factor Stimulus
Pathways			Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Drugs
Diseases
GWAS			Liver enzyme levels (alkaline phosphatase) ( 33972514) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Periodontitis (DPAL) ( 24024966) Response to methotrexate in juvenile idiopathic arthritis ( 24709693)
Interacting Genes		7 interacting genes: APP FBXO7 LATS1 LATS2 NEDD4 NEDD4L TGIF1	21 interacting genes: A2M APP AR CTBP1 CTBP2 EEF1A1 HDAC1 HMGB1 IRF2BP1 JUN LRIF1 MAPK1 MAPK3 MDFI MED31 MOB3A PML SIN3A SMAD2 SMAD3 WWP1
Entrez ID		126308	7050
HPRD ID		17583	04023
Ensembl ID		ENSG00000172081	ENSG00000177426
Uniprot IDs		Q96BX8	Q15583
PDB IDs			2LK2 6FQP 6FQQ
Enriched GO Terms of Interacting Partners?
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