CLIC1 and NTF4

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		CLIC1	NTF4
Description		chloride intracellular channel 1	neurotrophin 4
Image
GO Annotations	Cellular Component	Extracellular Space Nucleus Nuclear Envelope Cytoplasm Mitochondrion Plasma Membrane Brush Border Membrane Nuclear Membrane Vesicle Chloride Channel Complex Perinuclear Region Of Cytoplasm Extracellular Exosome Blood Microparticle	Extracellular Region Extracellular Space Synaptic Vesicle Axon Dendrite
	Molecular Function	Voltage-gated Ion Channel Activity Chloride Channel Activity Protein Binding Cadherin Binding	Nerve Growth Factor Receptor Binding Protein Binding Growth Factor Activity
	Biological Process	Glutathione Metabolic Process Chloride Transport Signal Transduction Ion Transmembrane Transport Regulation Of Ion Transmembrane Transport Positive Regulation Of Osteoblast Differentiation Regulation Of Cell Cycle Regulation Of Mitochondrial Membrane Potential Platelet Aggregation	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Ganglion Mother Cell Fate Determination Peripheral Nervous System Development Memory Long-term Memory Sensory Organ Boundary Specification Adult Locomotory Behavior Epidermis Development Nerve Development Positive Regulation Of Peptidyl-serine Phosphorylation Nerve Growth Factor Signaling Pathway Mechanoreceptor Differentiation Negative Regulation Of Neuron Apoptotic Process Regulation Of Neuron Differentiation Neuron Projection Morphogenesis Modulation Of Chemical Synaptic Transmission Innervation Taste Bud Development
Pathways			NTF4 activates NTRK2 (TRKB) signaling Activated NTRK2 signals through RAS Activated NTRK2 signals through PLCG1 Activated NTRK2 signals through PLCG1 Activated NTRK2 signals through PI3K Activated NTRK2 signals through FRS2 and FRS3 Activated NTRK2 signals through FRS2 and FRS3
Drugs		Copper Artenimol
Diseases
GWAS		Adult body size ( 32376654) Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Inflammatory bowel disease ( 28067908) Mean platelet volume ( 27863252) Ulcerative colitis ( 28067908)	Asparaginase-induced acute pancreatitis in acute lymphoblastic leukemia (onset time) ( 27114598)
Interacting Genes		24 interacting genes: AKAP9 ALOX5AP ATP5PB ATP6V0A1 ATP6V0C CPT1A DNAJC19 IKBKG LSM1 MEOX2 MYOC NHSL2 NTF4 NUP62 PCSK5 PRDX4 PSMD10 RPLP1 SUMO4 THRA TPRN TRAPPC2 ZNF184 ZNF302	8 interacting genes: ADAMTSL4 BDNF CLIC1 CRX GLRX3 LRP1 NGFR NTRK2
Entrez ID		1192	4909
HPRD ID		04188	01220
Ensembl ID		ENSG00000213719	ENSG00000225950
Uniprot IDs		O00299 Q53FB0 Q5SRT3	A0A024QZE4 P34130
PDB IDs		1K0M 1K0N 1K0O 1RK4 3O3T 3P8W 3P90 3QR6 3SWL 3TGZ 3UVH 4IQA 4JZQ 4K0G 4K0N	1B8M 1B98 1HCF
Enriched GO Terms of Interacting Partners?
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