AP2M1 and C1orf35

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		AP2M1	C1orf35
Description		adaptor related protein complex 2 subunit mu 1	chromosome 1 open reading frame 35
Image			No pdb structure
GO Annotations	Cellular Component	Lysosomal Membrane Cytosol Plasma Membrane Clathrin-coated Pit AP-2 Adaptor Complex Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Cytoplasmic Vesicle Endolysosome Membrane Clathrin-coated Endocytic Vesicle Extracellular Exosome Presynapse Postsynapse Glutamatergic Synapse	Extracellular Region Secretory Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	Signal Sequence Binding Protein Binding Lipid Binding Clathrin Adaptor Activity Transmembrane Transporter Binding Low-density Lipoprotein Particle Receptor Binding Disordered Domain Specific Binding	RNA Binding Protein Binding
	Biological Process	Positive Regulation Of Receptor Internalization Intracellular Protein Transport Endocytosis Vesicle Budding From Membrane Vesicle-mediated Transport Receptor Internalization Cellular Protein-containing Complex Assembly Synaptic Vesicle Endocytosis Clathrin-dependent Endocytosis Regulation Of Vesicle Size Postsynaptic Neurotransmitter Receptor Internalization Positive Regulation Of Synaptic Vesicle Endocytosis Negative Regulation Of Protein Localization To Plasma Membrane
Pathways		Nef mediated downregulation of CD28 cell surface expression Nef Mediated CD4 Down-regulation Retrograde neurotrophin signalling Retrograde neurotrophin signalling Nef Mediated CD8 Down-regulation Gap junction degradation Formation of annular gap junctions MHC class II antigen presentation EPH-ephrin mediated repulsion of cells Recycling pathway of L1 Recycling pathway of L1 WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDLR internalisation and degradation LDL clearance Potential therapeutics for SARS	Neutrophil degranulation
Drugs
Diseases
GWAS		Major depressive disorder ( 22472876)
Interacting Genes		87 interacting genes: ADRA1B AGTR1 AP2B1 AQP4 ARRB2 ATXN1L BDKRB2 C1orf35 CACNA1A CD22 CD3D CDK11B CKS1B CORO7 CRIP1 CSNK2B CTLA4 CXorf51A CXorf51B DAB2 DCX DNAJB11 DPPA2 DVL2 EAF1 EHD2 EIF1AD EIF4G1 ETV5 FAM90A1 FGF12 FURIN FXR2 GAK GRIN2A GRIN2B H2BC10 H2BC13 H2BC21 H2BC4 H2BC6 H2BC7 H2BC8 HEXIM2 HTR6 IKZF1 IL1RAP JADE1 KCNJ11 KNOP1 LAMP1 LPP LTB4R2 LY9 MAB21L3 MED4 MEGF10 MFAP1 MPP1 MTURN NAA11 NCOR2 NDRG1 NKAPD1 PRPF18 PRPF38A PRR13 PTS RALBP1 RNF111 RPL22 RPL38 RRP12 RSPH14 RUNDC3A SFRP4 STON2 SYNJ1 TASOR TBC1D5 TGOLN2 TMA16 UBC UTP25 XPA ZBTB8A ZNF581	40 interacting genes: AP2M1 APP ARL6IP4 C4orf45 CCNL1 CEP70 CSNK2A1 CT45A1 DACH1 DVL3 FAM133A FXR1 FXR2 GAS8 GKAP1 GOLGA2 GOLGA6L9 HSF2BP INCA1 MID2 MIPOL1 MTUS2 NKAPD1 PICK1 PLEKHF2 RBMX2 RINT1 RNF151 RP9 SDCBP SDCBP2 SRPK2 SRRM4 STAC3 TERF1 THAP1 TRIM54 TRIM55 TRIM63 ZRANB1
Entrez ID		1173	79169
HPRD ID		03014	10090
Ensembl ID		ENSG00000161203	ENSG00000143793
Uniprot IDs		B4DNB9 E9PFW3 Q96CW1	Q9BU76
PDB IDs		1H6E 6BNT 6URI
Enriched GO Terms of Interacting Partners?
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