CLNK and SFMBT1

Number of citations of the paper that reports this interaction (PubMedID 25814554)
26

Data Source:
BioGRID (two hybrid)

		CLNK	SFMBT1
Description		cytokine dependent hematopoietic cell linker	Scm like with four mbt domains 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Protein-containing Complex Mast Cell Granule	Nucleus Nucleoplasm
	Molecular Function	Protein Binding Protein-containing Complex Binding	Chromatin Binding Transcription Corepressor Activity Protein Binding Histone Binding
	Biological Process	Positive Regulation Of Natural Killer Cell Cytokine Production Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cell Death Negative Regulation Of Natural Killer Cell Activation Intracellular Signal Transduction Mast Cell Degranulation	Chromatin Organization Spermatogenesis Cell Differentiation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Muscle Organ Development
Pathways
Drugs
Diseases
GWAS		Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Family history of Alzheimer's disease ( 30617256) Gout ( 33832965) Resistance to antihypertensive treatment in hypertension ( 28222112) Rheumatoid arthritis ( 30423114 24390342) Systemic lupus erythematosus ( 33536424 28714469) Takayasu arteritis ( 25604533) Urate levels ( 31578528) Uterine fibroid size (maximum dimension) ( 30196971) Vitiligo ( 22561518)	Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972) Body shape index ( 34021172) Chronic kidney disease ( 29124443) Creatinine levels ( 29124443) Disrupted circadian rhythm (low relative amplitude of rest-activity cycles) ( 30120083) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31152163 29124443) General cognitive ability ( 29844566) Gout ( 33832965 31578528) Haemorrhoidal disease ( 33888516) Hand grip strength ( 29691431) Height ( 28552196 31562340 31217584) Hip circumference ( 28552196) Hyperuricemia ( 29124443) Intelligence (MTAG) ( 29326435) Mental health study participation (completed survey) ( 31263887) Multiple sclerosis ( 31604244) Schizophrenia ( 28991256 23974872) Serum uric acid levels ( 30993211 29124443 29403010) Type 2 diabetes (age of onset) ( 28060188) Urate levels ( 31985003 31578528 23263486) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		30 interacting genes: ANKRD50 ARAP3 BMX COQ9 CRK CYB561D2 EGFR ERBB2 FAM217A GLIS3 GRB2 GSTCD JAKMIP1 LCP2 NME4 P4HA2 PACSIN3 PIK3R1 PIK3R3 PPP1R7 PTK7 RASSF1 RB1 RPAIN SFMBT1 SMARCD1 SOCS6 STK36 TXK WWOX	11 interacting genes: ACP1 CLNK FAM214B HOXB9 PHC1 PHC2 PSMA1 SCMH1 SPANXN2 SRPK1 ZCCHC10
Entrez ID		116449	51460
HPRD ID		14720	09539
Ensembl ID		ENSG00000109684	ENSG00000163935
Uniprot IDs		Q7Z7G1	A0A024R338 Q9UHJ3
PDB IDs
Enriched GO Terms of Interacting Partners?
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