ADCYAP1 and VIPR2

Number of citations of the paper that reports this interaction (PubMedID 8146174)
31

Data Source:
HPRD (in vitro, in vivo)

		ADCYAP1	VIPR2
Description		adenylate cyclase activating polypeptide 1	vasoactive intestinal peptide receptor 2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Neuron Projection Terminal Bouton Perikaryon	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Signaling Receptor Binding Neuropeptide Hormone Activity Protein Binding Pituitary Adenylate Cyclase Activating Polypeptide Activity Pituitary Adenylate Cyclase-activating Polypeptide Receptor Binding Peptide Hormone Receptor Binding	G Protein-coupled Receptor Activity Vasoactive Intestinal Polypeptide Receptor Activity G Protein-coupled Peptide Receptor Activity Peptide Hormone Binding
	Biological Process	Ovarian Follicle Development Behavioral Fear Response Histamine Secretion Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus Negative Regulation Of Acute Inflammatory Response To Non-antigenic Stimulus Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Neuropeptide Signaling Pathway Cell-cell Signaling Female Pregnancy Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Negative Regulation Of Muscle Cell Apoptotic Process Positive Regulation Of Neuron Projection Development Sensory Perception Of Pain CAMP-mediated Signaling Pituitary Gland Development Insulin Secretion Neuron Projection Development Positive Regulation Of Interleukin-6 Production Regulation Of Protein Localization Negative Regulation Of GTPase Activity Vasodilation Response To Starvation Negative Regulation Of Potassium Ion Transport Positive Regulation Of GTPase Activity Positive Regulation Of CAMP-mediated Signaling Response To Ethanol Negative Regulation Of Cell Cycle Positive Regulation Of Protein Kinase Activity Positive Regulation Of Transcription By RNA Polymerase II ATP Metabolic Process Positive Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Postsynaptic Membrane Potential Positive Regulation Of Growth Hormone Secretion Negative Regulation Of Glial Cell Proliferation Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Oligodendrocyte Progenitor Proliferation Cellular Response To Glucocorticoid Stimulus Positive Regulation Of Chemokine (C-C Motif) Ligand 5 Production Positive Regulation Of Somatostatin Secretion Positive Regulation Of Cold-induced Thermogenesis	Signal Transduction Cell Surface Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Cell-cell Signaling Negative Regulation Of Smooth Muscle Cell Proliferation
Pathways		NGF-independant TRKA activation G alpha (s) signalling events Glucagon-type ligand receptors ADORA2B mediated anti-inflammatory cytokines production	G alpha (s) signalling events Glucagon-type ligand receptors ADORA2B mediated anti-inflammatory cytokines production
Drugs		2,6-Diamino-Hexanoic Acid Amide
Diseases
GWAS		Body size at age 10 ( 32376654) Chronotype ( 30696823) Midgestational cytokine/chemokine levels (fetal genetic effect) ( 30134952) Obesity-related traits ( 23251661) Pancreas volume ( 34128465) Very long-chain saturated fatty acid levels (fatty acid 22:0) ( 25378659)	Academic attainment (English) ( 33594131) Corneal astigmatism ( 30306274) Diastolic blood pressure x quantitative lifestyle risk score interaction (1df test) ( 32227373) Diastolic blood pressure x quantitative lifestyle risk score interaction (2df test) ( 32227373) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Hearing loss in noise exposure ( 33242228) Myopia (pathological) ( 23406873) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Sub-foveal choroidal thickness ( 29844195)
Interacting Genes		8 interacting genes: ADCYAP1R1 CASP2 CPAMD8 MME SCTR SHH VIPR1 VIPR2	6 interacting genes: ADCYAP1 APP DBNDD2 ERBIN RGS14 VIP
Entrez ID		116	7434
HPRD ID		02369	03576
Ensembl ID		ENSG00000141433	ENSG00000106018
Uniprot IDs		B7Z222 P18509	P41587 X5D7Q6 X5DP12
PDB IDs		1GEA 2D2P 2JOD 6LPB 6M1I 6P9Y 6VN7	2X57
Enriched GO Terms of Interacting Partners?
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