NOSTRIN and GLA

		NOSTRIN	GLA
Description		nitric oxide synthase trafficking	galactosidase alpha
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GO Annotations	Cellular Component	Nucleus Cytoskeleton Plasma Membrane Endocytic Vesicle Membrane	Extracellular Region Cytoplasm Lysosome Golgi Apparatus Azurophil Granule Lumen Lysosomal Lumen Extracellular Exosome
	Molecular Function	DNA Binding Protein Binding	Catalytic Activity Alpha-galactosidase Activity Signaling Receptor Binding Protein Binding Hydrolase Activity Galactoside Binding Galactosylgalactosylglucosylceramidase Activity Protein Homodimerization Activity Raffinose Alpha-galactosidase Activity
	Biological Process	Endocytosis Signal Transduction Negative Regulation Of Transcription, DNA-templated	Oligosaccharide Metabolic Process Glycoside Catabolic Process Negative Regulation Of Nitric Oxide Biosynthetic Process Glycosylceramide Catabolic Process Glycosphingolipid Catabolic Process Negative Regulation Of Nitric-oxide Synthase Activity
Pathways		NOSTRIN mediated eNOS trafficking	Glycosphingolipid metabolism Neutrophil degranulation
Drugs			Migalastat
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Eosinophil counts ( 32888494) Granulocyte count ( 27863252) Height ( 28552196) Hip circumference adjusted for BMI ( 34021172) Mitochondrial DNA levels ( 25240745) Monocyte count ( 32888494 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 32888494 27863252)
Interacting Genes		7 interacting genes: APC GLA KDM1A MAGEA6 NOS3 PRMT6 TULP3	14 interacting genes: ANKRD30A CCR2 COL4A5 DUSP6 GPR17 GUCY2F HNRNPH2 MORF4L2 NAP1L3 NOSTRIN OGT PDE6B PLP1 TERT
Entrez ID		115677	2717
HPRD ID		06324	02357
Ensembl ID		ENSG00000163072	ENSG00000102393
Uniprot IDs		Q8IVI9	P06280 Q53Y83
PDB IDs		2YUN	1R46 1R47 3GXN 3GXP 3GXT 3HG2 3HG3 3HG4 3HG5 3LX9 3LXA 3LXB 3LXC 3S5Y 3S5Z 3TV8 4NXS 6IBK 6IBM 6IBR 6IBT
Enriched GO Terms of Interacting Partners?
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