TIRAP and SAMHD1

Number of citations of the paper that reports this interaction (PubMedID 21903422)
143

Data Source:
BioGRID (pull down)

		TIRAP	SAMHD1
Description		TIR domain containing adaptor protein	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Endocytic Vesicle Ruffle Membrane	Nucleus Nucleoplasm Plasma Membrane Site Of Double-strand Break Tetraspanin-enriched Microdomain
	Molecular Function	NAD+ Nucleosidase Activity Protein Kinase C Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Protein-macromolecule Adaptor Activity Toll-like Receptor 4 Binding Toll-like Receptor 2 Binding Identical Protein Binding	Nucleic Acid Binding Single-stranded DNA Binding RNA Binding Ribonuclease Activity Protein Binding GTP Binding Zinc Ion Binding DGTPase Activity Triphosphoric Monoester Hydrolase Activity DGTP Binding Identical Protein Binding Deoxynucleoside Triphosphate Hydrolase Activity
	Biological Process	MyD88-dependent Toll-like Receptor Signaling Pathway Inflammatory Response Cell Surface Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Activation Of NF-kappaB-inducing Kinase Activity Myeloid Cell Differentiation Positive Regulation Of B Cell Proliferation Positive Regulation Of Protein-containing Complex Assembly Response To Lipopolysaccharide Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-15 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Toll-like Receptor 4 Signaling Pathway TIRAP-dependent Toll-like Receptor 4 Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Regulation Of Innate Immune Response Positive Regulation Of Innate Immune Response Positive Regulation Of JNK Cascade Defense Response To Gram-positive Bacterium Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of ERK1 And ERK2 Cascade 3'-UTR-mediated MRNA Stabilization Cellular Response To Bacterial Lipopeptide Cellular Response To Lipoteichoic Acid Positive Regulation Of Neutrophil Chemotaxis Positive Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production	Double-strand Break Repair Via Homologous Recombination DGTP Catabolic Process Immune Response Cellular Response To DNA Damage Stimulus Deoxyribonucleotide Catabolic Process Somatic Hypermutation Of Immunoglobulin Genes Innate Immune Response Regulation Of Innate Immune Response DATP Catabolic Process Protein Homotetramerization Defense Response To Virus Negative Regulation Of Type I Interferon-mediated Signaling Pathway RNA Phosphodiester Bond Hydrolysis DNA Strand Resection Involved In Replication Fork Processing
Pathways		ER-Phagosome pathway MyD88:MAL(TIRAP) cascade initiated on plasma membrane MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4)	Nucleobase catabolism Interferon alpha/beta signaling
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Blood protein levels in cardiovascular risk ( 28369058) Eosinophil percentage of granulocytes ( 27863252) Neutrophil percentage of granulocytes ( 27863252)	Caffeine consumption from coffee or tea ( 33287642) Height ( 28552196)
Interacting Genes		26 interacting genes: APP ARAF BTK CASP1 CCDC47 CD247 DNAJC3 EIF2AK2 IL1RL1 IRAK1 IRAK2 IRAK4 LRRK1 LTN1 MPP3 MYD88 PCNA PRKRA SAMHD1 SOCS1 TICAM1 TICAM2 TLR2 TLR4 TRAF6 TRAM1	14 interacting genes: AAR2 ACTB APP ARAP3 DCAF1 DYSF FAM13B FBXO25 FBXO7 KIZ SUMO2 TIRAP TRIM21 XPO1
Entrez ID		114609	25939
HPRD ID		05878	08418
Ensembl ID		ENSG00000150455	ENSG00000101347
Uniprot IDs		A0A024R3M4 P58753	Q59H15 Q9Y3Z3
PDB IDs		2NDH 2Y92 3UB2 3UB3 3UB4 4FZ5 4LQD 5T7Q 5UZB	2E8O 3U1N 4BZB 4BZC 4CC9 4MZ7 4Q7H 4QFX 4QFY 4QFZ 4QG0 4QG1 4QG2 4QG4 4RXO 4RXP 4RXQ 4RXR 4RXS 4TNP 4TNQ 4TNR 4TNX 4TNY 4TNZ 4TO0 4TO1 4TO2 4TO3 4TO4 4TO5 4TO6 4ZWE 4ZWG 5AO0 5AO1 5AO2 5AO3 5AO4 6CM2 6DW3 6DW4 6DW5 6DW7 6DWD 6DWJ 6DWK 6TX0 6TXA 6TXC 6TXE 6TXF 6U6X 6U6Y 6U6Z 6XU1 6YOM
Enriched GO Terms of Interacting Partners?
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