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PHB2 and HDAC5
Number of citations of the paper that reports this interaction (PubMedID
15140878
)
43
Data Source:
HPRD
(in vivo, in vitro)
PHB2
HDAC5
Description
prohibitin 2
histone deacetylase 5
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Mitochondrion
Mitochondrial Outer Membrane
Mitochondrial Inner Membrane
Plasma Membrane
Cell Surface
Postsynaptic Density
Nuclear Matrix
Axon
Protein-containing Complex
Mitochondrial Prohibitin Complex
Presynaptic Active Zone
Cell Periphery
Glutamatergic Synapse
GABA-ergic Synapse
Histone Deacetylase Complex
Nucleus
Nucleoplasm
Cytoplasm
Golgi Apparatus
Cytosol
Nuclear Speck
Molecular Function
Protein Binding
Protein C-terminus Binding
Estrogen Receptor Binding
Amide Binding
Identical Protein Binding
Protein Homodimerization Activity
Sphingolipid Binding
Protein Heterodimerization Activity
Protein N-terminus Binding
Transcription Cis-regulatory Region Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
Histone Deacetylase Activity
Protein Kinase C Binding
Protein Binding
Transcription Factor Binding
NAD-dependent Histone Deacetylase Activity (H3-K14 Specific)
Protein Deacetylase Activity
Identical Protein Binding
Histone Deacetylase Binding
Metal Ion Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
DNA-binding Transcription Factor Binding
Biological Process
Mitophagy
Positive Regulation Of Immunoglobulin Production
Protein Import Into Nucleus
Mitochondrion Organization
Sister Chromatid Cohesion
Activation Of Phospholipase C Activity
Response To Wounding
Cell Migration
CD40 Signaling Pathway
Regulation Of Complement Activation
Positive Regulation Of Exit From Mitosis
Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway
Negative Regulation Of Mammary Gland Epithelial Cell Proliferation
Induction By Virus Of Host Autophagy
RIG-I Signaling Pathway
B Cell Activation
Negative Regulation Of Apoptotic Process
Positive Regulation Of MAPK Cascade
Negative Regulation Of DNA-binding Transcription Factor Activity
Negative Regulation Of Transcription, DNA-templated
Protein Stabilization
Positive Regulation Of DNA-binding Transcription Factor Activity
Mammary Gland Branching Involved In Thelarche
Mammary Gland Alveolus Development
Regulation Of Branching Involved In Mammary Gland Duct Morphogenesis
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Retinoic Acid
Cellular Response To Hypoxia
Antiviral Innate Immune Response
Regulation Of Cardiolipin Metabolic Process
Positive Regulation Of NIK/NF-kappaB Signaling
Positive Regulation Of Cell Cycle G1/S Phase Transition
Regulation Of Cytochrome-c Oxidase Activity
Activation Of Protein Kinase C Activity
Negative Regulation Of Transcription By RNA Polymerase II
Chromatin Organization
Chromatin Remodeling
Protein Deacetylation
Inflammatory Response
Regulation Of Myotube Differentiation
Negative Regulation Of Myotube Differentiation
Histone Deacetylation
B Cell Differentiation
Cellular Response To Insulin Stimulus
Regulation Of Gene Expression, Epigenetic
B Cell Activation
Regulation Of Protein Binding
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of DNA-binding Transcription Factor Activity
Histone H3 Deacetylation
Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Regulation Of Histone H3-K9 Acetylation
Pathways
Processing of SMDT1
NOTCH1 Intracellular Domain Regulates Transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Notch-HLH transcription pathway
Regulation of PTEN gene transcription
Drugs
Capsaicin
Rocaglamide
Didesmethylrocaglamide
Belinostat
Panobinostat
Diseases
GWAS
Glycated hemoglobin levels (
34059833
28898252
)
Red blood cell fatty acid levels (
25500335
)
Refractive error (
32231278
)
Apolipoprotein A1 levels (
32203549
)
Bipolar disorder (
33263727
31043756
)
Bone mineral density (hip) (
19801982
)
Bone mineral density (spine) (
19801982
)
HDL cholesterol levels (
32203549
)
Heel bone mineral density (
30598549
28869591
)
Mean platelet volume (
32888494
)
Interacting Genes
24 interacting genes:
AFP
AKT1
CDC42
ESR1
EZH2
FHL2
HDAC1
HDAC2
HDAC3
HDAC5
MAP1LC3A
MEF2A
MRPS18B
MYOD1
NR2F1
NR2F2
PPARG
PPP1CA
PRKCA
PTEN
PTMA
RNF2
TEAD3
UPF2
69 interacting genes:
ADGRB2
ANKRA2
ANKRD11
ATF3
BCL6
BCOR
BRMS1
CAMK1
CAMTA2
CBX5
CIITA
CTBP1
DDX20
DYRK1B
EEF1G
ESR1
GABARAP
GATA1
GATA2
GCM1
GNB1
GOSR2
H3C1
HDAC3
HDAC7
HIF1A
HOXC11
HR
JDP2
KLF4
LMO2
MAFF
MEF2A
MEF2C
MEF2D
NCOR1
NCOR2
NFATC1
NFKB2
NFKBIE
NRIP1
PHB2
PKN1
PKN2
PRKAA1
PRKCD
PRKD1
PSME3
RFXANK
RUNX3
SFN
SGCA
SIK1
SIK2
SIK3
SLC2A4RG
SMAD3
SPARC
ST3GAL3
SUV39H1
TAB2
UBC
UBE2I
UTP18
VAT1
YWHAB
YWHAE
YWHAQ
ZBTB16
Entrez ID
11331
10014
HPRD ID
17843
09246
Ensembl ID
ENSG00000215021
ENSG00000108840
Uniprot IDs
Q99623
Q9UQL6
PDB IDs
6IQE
5UWI
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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