POU6F2 and ACTN3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		POU6F2	ACTN3
Description		POU class 6 homeobox 2	actinin alpha 3
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Cytosol Actin Filament Plasma Membrane Brush Border Focal Adhesion Z Disc Cell Junction Cortical Actin Cytoskeleton Pseudopodium Cell Projection Extracellular Exosome
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding	Integrin Binding Calcium Ion Binding Protein Binding Structural Constituent Of Muscle Identical Protein Binding Transmembrane Transporter Binding Actin Filament Binding
	Biological Process	Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Ganglion Mother Cell Fate Determination Central Nervous System Development Visual Perception	Muscle Contraction Regulation Of The Force Of Skeletal Muscle Contraction Skeletal Muscle Atrophy Transition Between Fast And Slow Fiber Response To Denervation Involved In Regulation Of Muscle Adaptation Actin Cytoskeleton Organization Positive Regulation Of Fast-twitch Skeletal Muscle Fiber Contraction Regulation Of Apoptotic Process Negative Regulation Of Glycolytic Process Focal Adhesion Assembly Positive Regulation Of Skeletal Muscle Tissue Growth Positive Regulation Of Skeletal Muscle Fiber Development Muscle Cell Development Bone Morphogenesis Negative Regulation Of Calcineurin-NFAT Signaling Cascade Negative Regulation Of Oxidative Phosphorylation Negative Regulation Of Cold-induced Thermogenesis Positive Regulation Of Bone Mineralization Involved In Bone Maturation Negative Regulation Of Relaxation Of Muscle Regulation Of Aerobic Respiration Positive Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate
Pathways			Nephrin family interactions Striated Muscle Contraction
Drugs
Diseases
GWAS		Adult body size ( 32376654) Attention deficit hyperactivity disorder (inattention symptoms) ( 32595297) Caffeine consumption from tea ( 33287642) Eye color ( 33692100) Feeling hurt ( 29500382) Glaucoma (multi-trait analysis) ( 31959993) Glaucoma (primary open-angle) ( 33627673) Hand grip strength ( 29691431) Intraocular pressure ( 29785010 31959993 30054594) Motion sickness ( 25628336) Refractive error ( 32231278) Tea consumption ( 31046077)	Bipolar disorder ( 21926972) Frontotemporal dementia with GRN mutation ( 29724592)
Interacting Genes		143 interacting genes: ACTN3 ANKRD10 ARHGEF6 ASB13 BANP BFSP2 BHLHE40 C1orf109 C5 CCHCR1 CCNC CCNK CDC23 CDC37 CDKN2C CHAF1A CIB3 CINP CSNK2A1 CSTF2 CTNNA3 DDX6 DTNB DYDC1 EBF1 EIF3F EIF4EBP1 EPHB6 FHL2 FNDC3B FOSB GCM2 GLIS2 GMEB2 GOLGA6L9 HGS HIVEP1 HNF1B HOXC5 HOXC8 HSPA4 IGFN1 IMPDH2 IQUB IRX4 ISX KDF1 KIF5B KLHL11 KPNA5 KPNA6 KRTAP8-1 L3MBTL2 LARP4 LMNB2 LMO3 LNX1 LONRF1 MAGEA12 MAPK9 MEIS2 MIEN1 MLLT10 MORF4L2 MSRB3 MSX2 MYL7 MYO15B NEUROG3 NFYC NKX3-2 NME7 NUP62CL OAZ3 OIP5 OPLAH OPTN PADI4 PARVG PDE6H PIBF1 PKN1 PM20D2 POLR3C POU2F1 PPIL1 PPIP5K2 PROP1 PRR20A PRR20B PRR20C PRR20D PRR20E QRICH1 RAD23B RBM39 RBPMS RELA SIX1 SMAD5 SMYD1 SORL1 SOX10 SSUH2 STAC STRA8 TBX6 TCEA2 TENT5B THADA THAP1 TLX2 TLX3 TNPO2 TNXB TP53BP1 TRIM73 TRIML2 TSC1 TSEN15 TTC19 TTC23 UBAC1 UFSP1 VAX2 VENTX VEZF1 VPS9D1 XPOT ZBTB24 ZBTB4 ZFHX2 ZFHX3 ZFP1 ZFP91 ZIM2 ZMYND12 ZNF148 ZNF319 ZNF34 ZNF384 ZNF410 ZNF574	64 interacting genes: ABI3 ACTN1 ACTN2 ACTN4 ADORA2A ASB9 ATP23 BBS1 BRCA1 C1orf94 C20orf85 C2CD6 CADPS CTAG1A CTAG1B CTDSP1 CXCL5 DDAH2 DUX1 DUX4L9 DYNC1I2 ECM1 FAM90A1 GLIS2 HGS HOXD12 HSF2BP IVD KCTD6 KRT6C LHX3 LINC01554 LNX1 MAGEA6 MICALL2 MYOT MYOZ1 MYPN NDUFAB1 NEBL NKAPD1 NRAP ODF3B PCCB PKP2 PLEKHG2 POU6F2 PPP1R18 PTK6 REL RNF111 RTP5 SNAI1 SOHLH1 SUMO1P1 SYNPO2L TRAF1 TRAF2 TRIM29 TTN USP2 XPO1 ZNF343 ZNF426
Entrez ID		11281	89
HPRD ID		10162	02148
Ensembl ID		ENSG00000106536	ENSG00000248746
Uniprot IDs		P78424	A0A087WSZ2 B4DZQ2 Q08043
PDB IDs			1TJT 1WKU 3LUE
Enriched GO Terms of Interacting Partners?
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