KLHL2 and BCAM

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid, two hybrid)

		KLHL2	BCAM
Description		kelch like family member 2	basal cell adhesion molecule (Lutheran blood group)
Image
GO Annotations	Cellular Component	Ruffle Cytoplasm Cytosol Actin Cytoskeleton Lamellipodium Cul3-RING Ubiquitin Ligase Complex	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Actin Binding Protein Binding Identical Protein Binding	Transmembrane Signaling Receptor Activity Laminin Receptor Activity Protein Binding Protein C-terminus Binding Laminin Binding
	Biological Process	Protein Ubiquitination	Cell Adhesion Cell-matrix Adhesion Signal Transduction
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Cognitive function ( 24684796) General cognitive ability ( 29844566) Neuroticism ( 27067015)	Alzheimer's disease ( 30636644 24755620) Alzheimer's disease (onset between ages 58 and 79) ( 30979435) Alzheimer's disease in hypertension ( 31055733) Alzheimer's disease in hypertension-negative individuals ( 31055733) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Blood protein levels ( 30072576 29875488) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Carotid intima media thickness (maximum) ( 31801372) Carotid intima media thickness (mean) ( 31801372) Cerebrospinal AB1-42 levels in Alzheimer's disease dementia ( 29274321) Cerebrospinal AB1-42 levels in mild cognitive impairment ( 29274321) Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Cerebrospinal fluid AB1-42 levels ( 28247064 29274321) Cerebrospinal fluid p-tau levels ( 29274321) Cerebrospinal fluid p-tau levels in mild cognitive impairment ( 29274321) Cerebrospinal fluid t-tau levels ( 29274321) Cerebrospinal fluid t-tau levels in mild cognitive impairment ( 29274321) Hippocampal volume ( 29274321) Hippocampal volume in Alzheimer's disease dementia ( 29274321) LDL cholesterol ( 30275531) Liver enzyme levels (alkaline phosphatase) ( 33972514) Logical memory (delayed recall) ( 29274321) Logical memory (immediate recall) ( 29274321) Waist-to-hip circumference ratio (smoking years interaction) ( 23192594)
Interacting Genes		32 interacting genes: ACTC1 BCAM BYSL C20orf85 CCDC43 CDC37 CLK2 CUL3 CWC22 ELOA FRAS1 KEAP1 KLHL12 KLHL3 MFAP1 NAP1L2 NTAQ1 PADI6 PIBF1 POLR3C SDCBP TMA16 TNPO2 TRIM50 TXNDC12 UBE2C UBE2D1 UBE2I UCK1 WNK1 WNK4 ZNF114	10 interacting genes: EPB41 KLHL2 KRTAP1-1 KRTAP1-3 LAMA5 MDFI NBPF19 NOTCH2NLA TRIM7 UBE2I
Entrez ID		11275	4059
HPRD ID		09311	00197
Ensembl ID		ENSG00000109466	ENSG00000187244
Uniprot IDs		B4DFZ5 E9PEX9 O95198	A0A087WXM8 P50895
PDB IDs		2XN4 4CHB	2PET 2PF6
Enriched GO Terms of Interacting Partners?
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