EGLN3 and SRP54

Number of citations of the paper that reports this interaction (PubMedID 26972000)
27

Data Source:
BioGRID (affinity chromatography technology)

		EGLN3	SRP54
Description		egl-9 family hypoxia inducible factor 3	signal recognition particle 54
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Nucleus Nucleolus Cytoplasm Endoplasmic Reticulum Signal Recognition Particle, Endoplasmic Reticulum Targeting Cytosol Nuclear Speck
	Molecular Function	Protein Binding Ferrous Iron Binding 2-oxoglutarate-dependent Dioxygenase Activity L-ascorbic Acid Binding Peptidyl-proline Dioxygenase Activity Peptidyl-proline 4-dioxygenase Activity	RNA Binding GTPase Activity Protein Binding GTP Binding 7S RNA Binding GDP Binding Endoplasmic Reticulum Signal Peptide Binding Ribonucleoprotein Complex Binding
	Biological Process	Response To Hypoxia Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Response To DNA Damage Stimulus Protein Hydroxylation Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Regulation Of Cell Population Proliferation Regulation Of Neuron Apoptotic Process Cellular Response To Hypoxia	SRP-dependent Cotranslational Protein Targeting To Membrane SRP-dependent Cotranslational Protein Targeting To Membrane, Translocation SRP-dependent Cotranslational Protein Targeting To Membrane, Signal Sequence Recognition Neutrophil Chemotaxis Granulocyte Differentiation Exocrine Pancreas Development Protein Targeting To ER
Pathways		Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane
Drugs		Ascorbic acid Roxadustat
Diseases
GWAS		Alzheimer's disease (late onset) ( 30820047) Daytime sleep phenotypes ( 27126917) Hematocrit ( 32888494 27863252) Hemoglobin ( 32888494) Iron status biomarkers (ferritin levels) ( 33536631) Red blood cell count ( 32888494)	Heel bone mineral density ( 30598549) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Immunoglobulin light chain (AL) amyloidosis ( 28025584)
Interacting Genes		39 interacting genes: ABI2 ADRB2 ATF4 CTBP2 DUSP7 EFHC2 EPAS1 EPOR FAM168B FOXJ2 GSC2 HIF1A HIF3A IK IKBKG IKZF3 LDB2 LNX1 MAPK1 MAPK7 MDM2 NCAPH2 NTAQ1 OS9 PKM PLEKHA2 PRPF19 RBBP8NL SERTAD1 SIAH2 SRP54 SUMO1 SUMO2 SUMO3 TP53 TTC23L WDR83 ZC2HC1A ZNF655	9 interacting genes: EGLN3 KLK12 OGT PRORP RALGAPA1 RNPS1 SRP19 STAB1 TKTL1
Entrez ID		112399	6729
HPRD ID		06972	05330
Ensembl ID		ENSG00000129521	ENSG00000100883
Uniprot IDs		B3KVT0 F8W1G2 Q3T1B0 Q9H6Z9	G3V480 P61011
PDB IDs			1MFQ 1QB2 5L3Q 6Y2Z 6Y30 6Y31 6Y32
Enriched GO Terms of Interacting Partners?
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