DUSP10 and IGF1R

Number of citations of the paper that reports this interaction (PubMedID 28065597)
37

Data Source:
BioGRID (two hybrid)

		DUSP10	IGF1R
Description		dual specificity phosphatase 10	insulin like growth factor 1 receptor
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Nuclear Speck	Plasma Membrane Integral Component Of Plasma Membrane Insulin Receptor Complex Membrane Axon Alphav-beta3 Integrin-IGF-1-IGF1R Complex Intracellular Membrane-bounded Organelle Receptor Complex Protein Kinase Complex
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/threonine Phosphatase Activity JUN Kinase Binding Phosphatase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity MAP Kinase Phosphatase Activity Mitogen-activated Protein Kinase P38 Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Insulin-activated Receptor Activity Insulin-like Growth Factor-activated Receptor Activity Insulin Receptor Binding Protein Binding Insulin-like Growth Factor Binding ATP Binding Insulin-like Growth Factor I Binding Identical Protein Binding Phosphatidylinositol 3-kinase Binding Insulin Binding Insulin Receptor Substrate Binding Protein Transporter Activity
	Biological Process	Regulation Of Adaptive Immune Response Negative Regulation Of Epithelial Cell Migration Dephosphorylation Negative Regulation Of Cell Migration Response To Lipopolysaccharide Peptidyl-threonine Dephosphorylation Negative Regulation Of MAPK Cascade Negative Regulation Of JUN Kinase Activity Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Positive Regulation Of Regulatory T Cell Differentiation Negative Regulation Of JNK Cascade Oligodendrocyte Differentiation Negative Regulation Of Oligodendrocyte Differentiation Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Respiratory Burst Involved In Inflammatory Response Negative Regulation Of ERK1 And ERK2 Cascade Regulation Of Brown Fat Cell Differentiation Negative Regulation Of P38MAPK Cascade Negative Regulation Of Epithelium Regeneration Peptidyl-tyrosine Dephosphorylation Involved In Inactivation Of Protein Kinase Activity	Immune Response Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Positive Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Cell Migration Positive Regulation Of Kinase Activity Peptidyl-tyrosine Autophosphorylation Glucose Homeostasis Negative Regulation Of Apoptotic Process Positive Regulation Of Protein-containing Complex Disassembly Negative Regulation Of MAPK Cascade Positive Regulation Of MAPK Cascade Transcytosis Regulation Of JNK Cascade Protein Autophosphorylation Insulin-like Growth Factor Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Protein Kinase B Signaling Cellular Response To Glucose Stimulus Dendritic Spine Maintenance Amyloid-beta Clearance Positive Regulation Of Cold-induced Thermogenesis Cellular Response To Amyloid-beta
Pathways		RAF-independent MAPK1/3 activation Negative regulation of MAPK pathway Signaling by MAPK mutants	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) IRS-related events triggered by IGF1R SHC-related events triggered by IGF1R Extra-nuclear estrogen signaling
Drugs			Insulin human Insulin lispro Insulin glargine Insulin pork Mecasermin Insulin aspart Insulin detemir Insulin glulisine Phosphoaminophosphonic Acid-Adenylate Ester ATL1101 XL228 rhIGFBP-3 Linsitinib Teprotumumab (4Z)-6-bromo-4-({[4-(pyrrolidin-1-ylmethyl)phenyl]amino}methylidene)isoquinoline-1,3(2H,4H)-dione 3-[5-(1H-IMIDAZOL-1-YL)-7-METHYL-1H-BENZIMIDAZOL-2-YL]-4-[(PYRIDIN-2-YLMETHYL)AMINO]PYRIDIN-2(1H)-ONE Somatrem Insulin degludec Cixutumumab Brigatinib Mecasermin rinfabate
Diseases
GWAS		Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Colorectal cancer ( 25990418 20972440 24836286 29471430) Colorectal cancer or advanced adenoma ( 30510241) Copper levels ( 26025379) Lung function (FEV1) ( 30061609) Lung function (FVC) ( 30061609) Progressive supranuclear palsy ( 30089514) Serum thyroid-stimulating hormone levels ( 25436638) Tonsillectomy ( 27182965 28928442) White matter lesion progression ( 26451028) White matter lesion progression (adjusted for white matter lesion burden at baseline) ( 26451028)	Adult body size ( 32376654) Alzheimer's disease ( 33074286) Arthritis (juvenile idiopathic) ( 22354554) Atrial fibrillation ( 30061737 29892015) Birth weight ( 31043758 27680694) Blood urea nitrogen levels ( 31152163 29403010) Creatinine levels ( 29124443 29403010) Dental caries (decayed and filled deciduous teeth) ( 31533690) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Endometriosis ( 27506219) Estimated glomerular filtration rate ( 31152163 31015462 29124443 30604766) Fasting glucose ( 33402679 34059833) Fasting plasma glucose ( 25187374) Global electrical heterogeneity phenotypes ( 29622589) Glomerular filtration rate ( 29403010) Height ( 28552196 20881960 25429064 31562340 33713608) Hemoglobin ( 32888494) Hip circumference adjusted for BMI ( 34021172) Hyperuricemia ( 29124443) Left ventricle wall thickness ( 33495596) Left ventricular mass ( 33495596) Left ventricular mass to end-diastolic volume ratio ( 33495596) Offspring birth weight ( 31043758) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494) Plateletcrit ( 32888494 27863252) QRS duration ( 30012220) Red cell distribution width ( 32888494) Refractive error ( 32231278) Risk-taking tendency (4-domain principal component model) ( 30643258) Rosacea symptom severity ( 29771307) Serum uric acid levels ( 30993211 29124443 29403010) Smoking status (ever vs never smokers) ( 30643258) Thyroid volume in Hashimotoâ€™s thyroiditis ( 32019955) TPE interval (resting) ( 32386560) Triglyceride levels ( 32203549) Type 2 diabetes ( 32499647) Urate levels ( 31985003 31578528 23263486) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		21 interacting genes: CMTM6 ERBB4 FHL2 FN1 FNDC3B HOXA1 HTT IGF1R KRTAP3-2 MAPK10 MAPK11 MAPK14 MAPK3 MAPK8 MAPK9 NEK2 PTK7 ROR2 RPS11 SLX1B SNX2	95 interacting genes: AMY2A APP ARHGEF12 BAP1 CAV1 CBL CDK4 CDKN2B CRK CRKL CSK CYP17A1 DOK4 DOK5 DUSP10 DUSP14 DUSP15 DUSP18 DUSP19 DUSP21 DUSP26 DUSP29 EEA1 EHD1 ERBB2 ESR1 FFAR2 FGFR4 GIPC1 GNAI1 GNAI2 GRB10 GRB14 GRM1 HOXC6 IGF1 IGF2 IGFBP3 IL13RA2 ILKAP INS INSR IRS1 IRS2 IRS4 ITGB1 JAK1 JAK2 KCNIP3 KDELR2 KL KLK5 KRT27 LYPD3 MAP3K5 MDM2 MTA3 NAT2 NEDD4 NF2 PCSK6 PIK3R1 PIK3R2 PIK3R3 PPM1A PRKCD PRKD1 PTPN1 PTPN11 PTPN12 PTPN6 PTPN7 PTPRR RACK1 RASA1 RELA RPL11 SH2B1 SHC1 SIRPA SOCS1 SOCS2 SOCS3 SRC STAT3 STYX THRSP TTYH2 UBC VAV3 VPS45 YWHAB YWHAE YWHAG YWHAZ
Entrez ID		11221	3480
HPRD ID		12320	00932
Ensembl ID		ENSG00000143507	ENSG00000140443
Uniprot IDs		Q9Y6W6	C9J5X1 P08069
PDB IDs		1ZZW 2OUC 2OUD 3TG1 6MC1	1IGR 1JQH 1K3A 1M7N 1P4O 2OJ9 2ZM3 3D94 3F5P 3I81 3LVP 3LW0 3NW5 3NW6 3NW7 3O23 3QQU 4D2R 4XSS 5FXQ 5FXR 5FXS 5HZN 5U8Q 5U8R 6JK8 6VWG 6VWH 6VWI 6VWJ
Enriched GO Terms of Interacting Partners?
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